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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

sigB  -  RNA polymerase sigma factor SigB

Listeria monocytogenes serotype 4b str. F2365

 
 
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Disease relevance of sigB

  • DNA sequencing of the sigB gene allowed differentiation of eight Listeria subtypes [1].
 

High impact information on sigB

  • These findings highlight the importance of complementing phenotypic characterizations with gene expression studies to identify direct and indirect effects of null mutations in regulatory genes, such as sigB [2].
  • Phylogenetic analyses of partial sigB and actA sequences showed that lineage III represents three distinct subgroups, which were termed IIIA, IIIB and IIIC [3].
 

Analytical, diagnostic and therapeutic context of sigB

  • We selected 157 Listeria isolates to evaluate a combination of a previously described multiplex PCR assay and sigB allelic typing as an alternative molecular serotyping and subtyping strategy for L. monocytogenes [4].

References

  1. Daily variability of Listeria contamination patterns in a cold-smoked salmon processing operation. Hu, Y., Gall, K., Ho, A., Ivanek, R., Gröhn, Y.T., Wiedmann, M. J. Food Prot. (2006) [Pubmed]
  2. SigmaB activation under environmental and energy stress conditions in Listeria monocytogenes. Chaturongakul, S., Boor, K.J. Appl. Environ. Microbiol. (2006) [Pubmed]
  3. Genetic and phenotypic characterization of Listeria monocytogenes lineage III. Roberts, A., Nightingale, K., Jeffers, G., Fortes, E., Kongo, J.M., Wiedmann, M. Microbiology (Reading, Engl.) (2006) [Pubmed]
  4. Combined sigB allelic typing and multiplex PCR provide improved discriminatory power and reliability for Listeria monocytogenes molecular serotyping. Nightingale, K., Bovell, L., Grajczyk, A., Wiedmann, M. J. Microbiol. Methods (2007) [Pubmed]
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