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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

C9  -  complement component 9

Bos taurus

 
 
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High impact information on C9

  • In the classical pathway of activation, bovine C8 and the ninth component of the complement system (C9) had species incompatibility with human C8 and C9 on sheep erythrocyte target cells [1].
  • The N-terminal difference is unimportant since microsequencing of bovine C9, which is strongly hemolytic, established that it also has an unblocked glycine identical to horse C9 [2].
  • The conditions for binding and elution from diethylaminoethyl cellulose and hydroxylapatite were different than for human C9 [3].
  • The calculated molecular weight of bovine C9 was 66,000, and reduction with 2-mercaptoethanol affected its migration on polyacrylamide gel electrophoresis [3].

References

  1. Isolation and characterization of the eighth component of the bovine complement system. Menger, M., Sowery, R.D., Aston, W.P. Am. J. Vet. Res. (1999) [Pubmed]
  2. Horse complement protein C9: primary structure and cytotoxic activity. Esser, A.F., Tarnuzzer, R.W., Tomlinson, S., Tatar, L.D., Stanley, K.K. Mol. Immunol. (1996) [Pubmed]
  3. Purification of the ninth component of the bovine complement cascade. Eisenschenk, F.C., Houle, J.J., Hoffmann, E.M. Am. J. Vet. Res. (1992) [Pubmed]
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