Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

HRG - histidine-rich glycoprotein

Bos taurus

Suzuki, K. et al., Vestergaard, A.B. et al.

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High impact information on HRG

Histidine-rich glycoprotein inhibits contact activation of blood coagulation [1].
The heifers were randomly assigned to the ILG (lactated Ringer's + 5% dextrose), HLG (1/2 lactated Ringer's + 2.2% dextrose) or HRG (1/2 Ringer's + 2.5% dextrose) groups with 3 heifers in each group [2].
The rapid intravenous (IV) infusions of HLG and HRG used in this study were found to be safe and effective in increasing plasma volume without increasing CVP, even though the infusion was given to the jugular vein at a dosage of 30 ml/kg [2].

Associations of HRG with chemical compounds

The effect of purified bovine histidine-rich glycoprotein on the contact activation of blood coagulation was studied in human plasma by using as activating surface either an ellagic acid-phospholipid suspension (Cephotest) or sulfatide [1].

References

Histidine-rich glycoprotein inhibits contact activation of blood coagulation. Vestergaard, A.B., Andersen, H.F., Magnusson, S., Halkier, T. Thromb. Res. (1990) [Pubmed]
Effect of isotonic and hypotonic lactated ringer's solutions with dextrose intravenously administered to dehydrated heifers. Suzuki, K., Okumura, J., Abe, I., Iwabuchi, S., Kanayama, K., Asano, R. J. Vet. Med. Sci. (2002) [Pubmed]

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