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Gene Review

TIE1  -  tyrosine kinase with immunoglobulin-like...

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High impact information on TIE

  • The present study demonstrates that Tie1 expression is rapidly down-regulated in endothelial cells exposed to shear stress, and more so to shear stress changes [1].
  • The rapid cleavage of Tie1 is followed by a transcriptional down-regulation in response to shear stress [1].
  • Shear stress-induced transcriptional suppression of Tie1 is mediated by a negative shear stress response element, localized in a region of 250 bp within the promoter [1].


  1. Transcriptional and post-translation regulation of the Tie1 receptor by fluid shear stress changes in vascular endothelial cells. Chen-Konak, L., Guetta-Shubin, Y., Yahav, H., Shay-Salit, A., Zilberman, M., Binah, O., Resnick, N. FASEB J. (2003) [Pubmed]
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