The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tie1  -  tyrosine kinase with immunoglobulin-like...

Mus musculus

Synonyms: D430008P04Rik, TIE, Tie, Tie-1, Tyrosine-protein kinase receptor Tie-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tie1


Psychiatry related information on Tie1


High impact information on Tie1


Chemical compound and disease context of Tie1


Biological context of Tie1


Anatomical context of Tie1


Associations of Tie1 with chemical compounds

  • We now report studies with Tie1/LacZ metanephric kidneys explanted in vitro at a stage when Tie1/LacZ-expressing cells surround nephron precursors but glomeruli are unformed [19].
  • We have characterized and evaluated a tetracycline-responsive endothelial-specific binary system during mouse development, by engineering several transgenic lines which drive the expression of a tetracycline-controlled transactivator (tTA) under the control of either the Tek or Tie promoters (driver lines) [21].
  • Regional VEGF-Flk-1/KDR was assessed using the small molecule inhibitor SU5416, which selectively inhibits the tyrosine kinase receptor Flk-1 [22].
  • The C-terminus of dynamin contains two clusters of SH3 domain binding proline motifs; these motifs may interact with known SH3 domain proteins during tyrosine kinase receptor activation [23].
  • VE-PTP, a receptor-type phosphotyrosine phosphatase, associates with the tyrosine kinase receptor Tie-2 and VE-cadherin and enhances the adhesive function of the latter [24].

Physical interactions of Tie1


Regulatory relationships of Tie1


Other interactions of Tie1

  • In contrast, interference with the Flt-4 pathway or the Tie-1 pathway was without significant effect [34].
  • Furthermore, Tie-1 was strongly induced during repair with a prolonged expression in diabetic mice, whereas Tie-2 expression was constitutive during normal repair but completely absent in diabetes-impaired healing [35].
  • Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs [18].
  • The FLT4 gene encodes a tyrosine kinase receptor related to the two identified receptors for vascular endothelial growth factor (VEGF), FLT1 and FLK1/KDR [36].
  • The tyrosine kinase receptor fetal liver kinase 1 (Flk-1) plays a crucial role in vasculogenesis and angiogenesis, but its target genes remain elusive [37].

Analytical, diagnostic and therapeutic context of Tie1


  1. A unique pattern of Tie1 expression in the developing murine lung. Taichman, D.B., Schachtner, S.K., Li, Y., Puri, M.C., Bernstein, A., Scott Baldwin, H. Exp. Lung Res. (2003) [Pubmed]
  2. Molecular and genetic analyses of renal capillary development: Studying the angiopoietin/Tie axis. Woolf, A.S. Kidney Int. (2005) [Pubmed]
  3. Angiopoietin-1, angiopoietin-2 and Tie-2 in tumour and non-tumour tissues during growth of experimental melanoma. Pomyje, J., Zivný, J.H., Stopka, T., Simák, J., Vanková, H., Necas, E. Melanoma Res. (2001) [Pubmed]
  4. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. Puri, M.C., Rossant, J., Alitalo, K., Bernstein, A., Partanen, J. EMBO J. (1995) [Pubmed]
  5. Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development. Partanen, J., Puri, M.C., Schwartz, L., Fischer, K.D., Bernstein, A., Rossant, J. Development (1996) [Pubmed]
  6. BDNF regulates eating behavior and locomotor activity in mice. Kernie, S.G., Liebl, D.J., Parada, L.F. EMBO J. (2000) [Pubmed]
  7. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C.T., Bryder, D., Yang, L., Borge, O.J., Thoren, L.A., Anderson, K., Sitnicka, E., Sasaki, Y., Sigvardsson, M., Jacobsen, S.E. Cell (2005) [Pubmed]
  8. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Colvin, J.S., Bohne, B.A., Harding, G.W., McEwen, D.G., Ornitz, D.M. Nat. Genet. (1996) [Pubmed]
  9. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Geissler, E.N., Ryan, M.A., Housman, D.E. Cell (1988) [Pubmed]
  10. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Baumann, C.A., Ribon, V., Kanzaki, M., Thurmond, D.C., Mora, S., Shigematsu, S., Bickel, P.E., Pessin, J.E., Saltiel, A.R. Nature (2000) [Pubmed]
  11. Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. Holmberg, J., Clarke, D.L., Frisén, J. Nature (2000) [Pubmed]
  12. The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically. Garofalo, A., Naumova, E., Manenti, L., Ghilardi, C., Ghisleni, G., Caniatti, M., Colombo, T., Cherrington, J.M., Scanziani, E., Nicoletti, M.I., Giavazzi, R. Clin. Cancer Res. (2003) [Pubmed]
  13. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Craft, N., Shostak, Y., Carey, M., Sawyers, C.L. Nat. Med. (1999) [Pubmed]
  14. Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism. Sagi, Y., Mandel, S., Amit, T., Youdim, M.B. Neurobiol. Dis. (2007) [Pubmed]
  15. Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells. Rodewald, H.R., Sato, T.N. Oncogene (1996) [Pubmed]
  16. Isolation and expression analysis of three zebrafish angiopoietin genes. Pham, V.N., Roman, B.L., Weinstein, B.M. Dev. Dyn. (2001) [Pubmed]
  17. Expressional regulation of the angiopoietin-1 and -2 and the endothelial-specific receptor tyrosine kinase Tie2 in adrenal atrophy: a study of adrenocorticotropin-induced repair. Féraud, O., Mallet, C., Vilgrain, I. Endocrinology (2003) [Pubmed]
  18. Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs. Teilmann, S.C., Christensen, S.T. Cell Biol. Int. (2005) [Pubmed]
  19. Effects of oxygen on vascular patterning in Tie1/LacZ metanephric kidneys in vitro. Loughna, S., Yuan, H.T., Woolf, A.S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  20. Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues. Koblizek, T.I., Runting, A.S., Stacker, S.A., Wilks, A.F., Risau, W., Deutsch, U. Eur. J. Biochem. (1997) [Pubmed]
  21. Conditional transgene expression in endothelial cells. Sarao, R., Dumont, D.J. Transgenic Res. (1998) [Pubmed]
  22. Measuring VEGF-Flk-1 activity and consequences of VEGF-Flk-1 targeting in vivo using intravital microscopy: clinical applications. Vajkoczy, P., Thurnher, A., Hirth, K.P., Schilling, L., Schmiedek, P., Ullrich, A., Menger, M.D. Oncologist (2000) [Pubmed]
  23. Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences. Scaife, R., Gout, I., Waterfield, M.D., Margolis, R.L. EMBO J. (1994) [Pubmed]
  24. Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Bäumer, S., Keller, L., Holtmann, A., Funke, R., August, B., Gamp, A., Wolburg, H., Wolburg-Buchholz, K., Deutsch, U., Vestweber, D. Blood (2006) [Pubmed]
  25. Interleukin-1beta regulates angiopoietin-1 expression in human endothelial cells. Fan, F., Stoeltzing, O., Liu, W., McCarty, M.F., Jung, Y.D., Reinmuth, N., Ellis, L.M. Cancer Res. (2004) [Pubmed]
  26. Generation of a specific immunological response to FGF-2 does not affect wound healing or reproduction. Plum, S.M., Vu, H.A., Mercer, B., Fogler, W.E., Fortier, A.H. Immunopharmacology and immunotoxicology. (2004) [Pubmed]
  27. Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation-induced hyperalgesia. Groth, R., Aanonsen, L. Pain (2002) [Pubmed]
  28. Alternatively spliced juxtamembrane domain of a tyrosine kinase receptor is a multifunctional regulatory site. Deletion alters cellular tyrosine phosphorylation pattern and facilitates binding of phosphatidylinositol-3-OH kinase to the hepatocyte growth factor receptor. Lee, C.C., Yamada, K.M. J. Biol. Chem. (1995) [Pubmed]
  29. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Stoeltzing, O., Ahmad, S.A., Liu, W., McCarty, M.F., Wey, J.S., Parikh, A.A., Fan, F., Reinmuth, N., Kawaguchi, M., Bucana, C.D., Ellis, L.M. Cancer Res. (2003) [Pubmed]
  30. Differentially expressed fibroblast growth factors regulate skeletal muscle development through autocrine and paracrine mechanisms. Hannon, K., Kudla, A.J., McAvoy, M.J., Clase, K.L., Olwin, B.B. J. Cell Biol. (1996) [Pubmed]
  31. Identification of a novel 135-kDa Grb2-binding protein in osteoclasts. Sahni, M., Zhou, X.M., Bakiri, L., Schlessinger, J., Baron, R., Levy, J.B. J. Biol. Chem. (1996) [Pubmed]
  32. High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways. Zhong, J., Deng, J., Huang, S., Yang, X., Lee, W.H. J. Neurosci. Res. (2004) [Pubmed]
  33. Negative regulation of c-kit-mediated cell proliferation by Fc gamma RIIB. Malbec, O., Fridman, W.H., Daëron, M. J. Immunol. (1999) [Pubmed]
  34. Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway. Siemeister, G., Schirner, M., Weindel, K., Reusch, P., Menrad, A., Marmé, D., Martiny-Baron, G. Cancer Res. (1999) [Pubmed]
  35. Expressional regulation of angiopoietin-1 and -2 and the tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: a comparative study of normal and impaired repair. Kämpfer, H., Pfeilschifter, J., Frank, S. Lab. Invest. (2001) [Pubmed]
  36. Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase. Borg, J.P., deLapeyrière, O., Noguchi, T., Rottapel, R., Dubreuil, P., Birnbaum, D. Oncogene (1995) [Pubmed]
  37. Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro. Zippo, A., De Robertis, A., Bardelli, M., Galvagni, F., Oliviero, S. Blood (2004) [Pubmed]
  38. Elf-1 is a transcriptional regulator of the Tie2 gene during vascular development. Dube, A., Thai, S., Gaspar, J., Rudders, S., Libermann, T.A., Iruela-Arispe, L., Oettgen, P. Circ. Res. (2001) [Pubmed]
  39. Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF. Hou, L., Panthier, J.J., Arnheiter, H. Development (2000) [Pubmed]
  40. Targeting endothelial growth with monoclonal antibodies against Tie-1 kinase in mouse models. Karnani, P., Kairemo, K. Clin. Cancer Res. (2003) [Pubmed]
WikiGenes - Universities