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Gene Review

Tie1  -  tyrosine kinase with immunoglobulin-like...

Rattus norvegicus

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Disease relevance of Tie1

  • Neither Ang1 nor Tie1 mRNA or protein showed any significant change at any time point after the infarction [1].
  • The expression of Tie-2 mRNA (4.3 kb), a receptor for Angpo-1, and Tie-1 mRNA (4.3 kb) also increased starting 24 hours after reperfusion and remained elevated for up to 2 weeks after ischemia [2].
  • Only VEGF and Tie1 were upregulated in response to hypoxia [3].

High impact information on Tie1


Biological context of Tie1

  • Based on these observations, we tested whether Tie1 and Tie2 mRNA and protein levels are regulated by cell density [8].

Anatomical context of Tie1

  • We examined the expression of Tie1 and Tie2 in normal vessels and during reendothelialization following balloon injury of the adult rat carotid artery [8].

Other interactions of Tie1


Analytical, diagnostic and therapeutic context of Tie1

  • Ang1 and Tie1 mRNA and protein did not show significant changes after ischaemia/reperfusion [9].
  • The mRNA expressions of angiogenic growth factors (vascular endothelial growth factor (VEGF) and angiopoietins 1 and 2) and their receptors (flt-1, flk-1, Tie-1 and Tie-2) in the whole liver were evaluated by semi-quantitative RT-PCR [10].
  • In agreement with the in situ hybridization study, Tie-1 immunoreactivity appeared as capillary-like structures in cortical layers 2 to 4 [5].
  • Western blot analysis showed a biphasic expression of Tie-1 protein in the same region [5].


  1. Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction. Shyu, K.G., Liang, Y.J., Chang, H., Wang, B.W., Leu, J.G., Kuan, P. J. Biomed. Sci. (2004) [Pubmed]
  2. Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion. Lin, T.N., Wang, C.K., Cheung, W.M., Hsu, C.Y. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  3. In vitro cultured rat islets express genes that both prevent and promote angiogenesis. Tillmar, L., Welsh, N. JOP (2004) [Pubmed]
  4. Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver. Ross, M.A., Sander, C.M., Kleeb, T.B., Watkins, S.C., Stolz, D.B. Hepatology (2001) [Pubmed]
  5. Induction of Tie-1 and Tie-2 receptor protein expression after cerebral ischemia-reperfusion. Lin, T.N., Nian, G.M., Chen, S.F., Cheung, W.M., Chang, C., Lin, W.C., Hsu, C.Y. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  6. Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells. Zheng, W., Christensen, L.P., Tomanek, R.J. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  7. Establishment of bone marrow-derived endothelial cell lines from ts-SV40 T-antigen gene transgenic rats. Hattori, K., Muta, M., Toi, M., Iizasa, H., Shinsei, M., Terasaki, T., Obinata, M., Ueda, M., Nakashima, E. Pharm. Res. (2001) [Pubmed]
  8. Expression of tie1 and tie2 proteins during reendothelialization in balloon-injured rat carotid artery. Fujikawa, K., Presman, E., Isner, J.M., Varticovski, L. J. Vasc. Res. (1999) [Pubmed]
  9. Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion. Shyu, K.G., Chang, C.C., Wang, B.W., Kuan, P., Chang, H. Clin. Sci. (2003) [Pubmed]
  10. Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver. Sato, T., El-Assal, O.N., Ono, T., Yamanoi, A., Dhar, D.K., Nagasue, N. J. Hepatol. (2001) [Pubmed]
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