The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Tie1  -  tyrosine kinase with immunoglobulin-like...

Rattus norvegicus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Tie1

  • Neither Ang1 nor Tie1 mRNA or protein showed any significant change at any time point after the infarction [1].
  • The expression of Tie-2 mRNA (4.3 kb), a receptor for Angpo-1, and Tie-1 mRNA (4.3 kb) also increased starting 24 hours after reperfusion and remained elevated for up to 2 weeks after ischemia [2].
  • Only VEGF and Tie1 were upregulated in response to hypoxia [3].
 

High impact information on Tie1

 

Biological context of Tie1

  • Based on these observations, we tested whether Tie1 and Tie2 mRNA and protein levels are regulated by cell density [8].
 

Anatomical context of Tie1

  • We examined the expression of Tie1 and Tie2 in normal vessels and during reendothelialization following balloon injury of the adult rat carotid artery [8].
 

Other interactions of Tie1

 

Analytical, diagnostic and therapeutic context of Tie1

  • Ang1 and Tie1 mRNA and protein did not show significant changes after ischaemia/reperfusion [9].
  • The mRNA expressions of angiogenic growth factors (vascular endothelial growth factor (VEGF) and angiopoietins 1 and 2) and their receptors (flt-1, flk-1, Tie-1 and Tie-2) in the whole liver were evaluated by semi-quantitative RT-PCR [10].
  • In agreement with the in situ hybridization study, Tie-1 immunoreactivity appeared as capillary-like structures in cortical layers 2 to 4 [5].
  • Western blot analysis showed a biphasic expression of Tie-1 protein in the same region [5].

References

  1. Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction. Shyu, K.G., Liang, Y.J., Chang, H., Wang, B.W., Leu, J.G., Kuan, P. J. Biomed. Sci. (2004) [Pubmed]
  2. Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion. Lin, T.N., Wang, C.K., Cheung, W.M., Hsu, C.Y. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  3. In vitro cultured rat islets express genes that both prevent and promote angiogenesis. Tillmar, L., Welsh, N. JOP (2004) [Pubmed]
  4. Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver. Ross, M.A., Sander, C.M., Kleeb, T.B., Watkins, S.C., Stolz, D.B. Hepatology (2001) [Pubmed]
  5. Induction of Tie-1 and Tie-2 receptor protein expression after cerebral ischemia-reperfusion. Lin, T.N., Nian, G.M., Chen, S.F., Cheung, W.M., Chang, C., Lin, W.C., Hsu, C.Y. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  6. Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells. Zheng, W., Christensen, L.P., Tomanek, R.J. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  7. Establishment of bone marrow-derived endothelial cell lines from ts-SV40 T-antigen gene transgenic rats. Hattori, K., Muta, M., Toi, M., Iizasa, H., Shinsei, M., Terasaki, T., Obinata, M., Ueda, M., Nakashima, E. Pharm. Res. (2001) [Pubmed]
  8. Expression of tie1 and tie2 proteins during reendothelialization in balloon-injured rat carotid artery. Fujikawa, K., Presman, E., Isner, J.M., Varticovski, L. J. Vasc. Res. (1999) [Pubmed]
  9. Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion. Shyu, K.G., Chang, C.C., Wang, B.W., Kuan, P., Chang, H. Clin. Sci. (2003) [Pubmed]
  10. Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver. Sato, T., El-Assal, O.N., Ono, T., Yamanoi, A., Dhar, D.K., Nagasue, N. J. Hepatol. (2001) [Pubmed]
 
WikiGenes - Universities