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Gene Review

ASAT  -  aspartyl aminotransferase

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Disease relevance of ASAT

  • Total liver enzyme activity (E) for aspartate aminotransferase (ASAT; EC per gram body weight (W) decreases in six species as body weight increases from mice to cattle according to the equation E/W 0.85 = c, where c is a constant [1].
  • There were signs of liver dysfunction in all the calves including increased aspartate aminotransferase (ASAT), glutamate dehydrogenase (GLDH) and gamma-glutamyltransferase activities [2].

High impact information on ASAT

  • The activities of serum aspartate aminotransferase (ASAT; p < 0.001), glutamate dehydrogenase (GLDH; p < 0.01) and gamma glutamyl transferase (gamma-GT; p < 0.01) increased with increasing OM intake and were not related to the mycotoxin contamination of the wheat [3].
  • In the four day period following surgery, in all groups mean serum levels of ASAT, GGT, GLDH and cholesterol remained nearly unchanged, whereas total bilirubin, NEFA, BHB and glucose decreased significantly (p < 0.05) [4].
  • The effect of serum glucose, ASAT and urea on reproductive performance was studied in 45 Finnish dairy cows from 8 different herds [5].
  • The 0.85 power of body weight thereby provides a reference standard for the direct arithmetic comparison of liver ASAT activities in six species with different body weights [1].
  • The serum activity of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), creatine kinase (CK), and gamma-glutamyltransferase (GGT) was determined at the time of first and subsequent treatments in milk fever cows which responded differently to treatment, and in a number of healthy, periparturient cows [6].

Associations of ASAT with chemical compounds

  • Glucose and ASAT concentrations were significantly correlated with fertility 2 weeks after calving, but not before calving or 2 months after calving [5].
  • ALAT, AP, ASAT, GGT, OCT activities and urea and total bilirubin concentrations in plasma of normal and ketotic dairy cows [7].

Analytical, diagnostic and therapeutic context of ASAT

  • CONCLUSIONS: Early reperfusion resulted in myocardial salvage as assessed by tetrazolium staining and peak ASAT, CK, and LD at 90 min after the reperfusion [8].


  1. Liver aspartate aminotransferase activity as a power function of body weight. Pappas, N.J., Qureshi, A.R. Biochem. Med. Metab. Biol. (1988) [Pubmed]
  2. Nephrotoxicity and hepatotoxicity in calves apparently caused by experimental feeding with Narthecium ossifragum. Flåøyen, A., Bratberg, B., Frøslie, A., Grønstøl, H. Vet. Res. Commun. (1995) [Pubmed]
  3. Effects of level of feed intake and Fusarium toxin-contaminated wheat on rumen fermentation as well as on blood and milk parameters in cows. Seeling, K., Lebzien, P., Dänicke, S., Spilke, J., Südekum, K.H., Flachowsky, G. Journal of animal physiology and animal nutrition. (2006) [Pubmed]
  4. Post surgical convalescence of dairy cows with left abomasal displacement in relation to fatty liver. Rehage, J., Mertens, M., Stockhofe-Zurwieden, N., Kaske, M., Scholz, H. Schweiz. Arch. Tierheilkd. (1996) [Pubmed]
  5. Correlation between energy balance and fertility in Finnish dairy cows. Miettinen, P.V. Acta Vet. Scand. (1991) [Pubmed]
  6. Milk fever in the cow--course of disease in relation to the serum activity of aspartate aminotransferase, alanine aminotransferase, creatine kinase and gamma-glutamyltransferase. Waage, S. Nordisk veterinaermedicin. (1984) [Pubmed]
  7. ALAT, AP, ASAT, GGT, OCT activities and urea and total bilirubin concentrations in plasma of normal and ketotic dairy cows. Kauppinen, K. Zentralblatt für Veterinärmedizin. Reihe A. (1984) [Pubmed]
  8. Effects of reperfusion and superoxide dismutase on myocardial infarct size in a closed chest pig model. Näslund, U., Häggmark, S., Johansson, G., Pennert, K., Reiz, S., Marklund, S.L. Cardiovasc. Res. (1992) [Pubmed]
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