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Gene Review:

AP3D1 - adaptor-related protein complex 3, delta 1...

Bos taurus

Ban, J. et al., Suzuki, T. et al., Popescu, C.P. et al., Orlik, O. et al., Ristau, E. et al.

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Disease relevance of AP3D1

The longest open reading frame of the BLV cell receptor gene encodes a protein containing 843 amino acids with a calculated molecular mass of 94.2 kDa which concurs with experimentally detected native BLV receptor protein [1].
Polyclonal bovine sera but not virus-neutralizing monoclonal antibodies block bovine leukemia virus (BLV) gp51 binding to recombinant BLV receptor BLVRcp1 [2].

High impact information on AP3D1

Part of the AP3delta cDNA isolated from the lymph node, spleen and MDBK cells, from which the BLVR candidate cDNA was derived, has almost the same nucleotide sequences as the boAP3delta cDNA [3].
The BLV receptor candidate gene has been localized precisely on cattle, goat, and sheep chromosomes using nonradioactive in situ hybridization and simultaneous fluorescent R-banding [4].
BLV receptor activity in plasma membranes from tumorous lymph nodes of BLV-infected cows [5].

References

Isolation of the missing 5'-end of the encoding region of the bovine leukemia virus cell receptor gene. Ban, J., Truong, A.T., Horion, B., Altaner, C., Burny, A., Portetelle, D., Kettmann, R. Arch. Virol. (1994) [Pubmed]
Polyclonal bovine sera but not virus-neutralizing monoclonal antibodies block bovine leukemia virus (BLV) gp51 binding to recombinant BLV receptor BLVRcp1. Orlik, O., Ban, J., Hlavaty, J., Altaner, C., Kettmann, R., Portetelle, D., Splitter, G.A. J. Virol. (1997) [Pubmed]
Evaluation of the delta subunit of bovine adaptor protein complex 3 as a receptor for bovine leukaemia virus. Suzuki, T., Matsubara, Y., Kitani, H., Ikeda, H. J. Gen. Virol. (2003) [Pubmed]
Chromosomal localization of the BLV receptor candidate gene in cattle, sheep, and goat. Popescu, C.P., Boscher, J., Hayes, H.C., Ban, J., Kettmann, R. Cytogenet. Cell Genet. (1995) [Pubmed]
BLV receptor activity in plasma membranes from tumorous lymph nodes of BLV-infected cows. Ristau, E., Roessler, H., Burkardt, H., Scholz, D., Rosenthal, S. Acta Virol. (1986) [Pubmed]

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AGOS_AFL076W	Ashbya gossypii ATCC 10895
AP3D1	Canis lupus familiaris
AP3D1	Gallus gallus
AP3D1	Homo sapiens
KLLA0E19405g	Kluyveromyces lactis NRRL Y-1140
AP3D1	Macaca mulatta
MGG_07481	Magnaporthe oryzae 70-15
Ap3d1	Mus musculus
NCU04652	Neurospora crassa OR74A
AP3D1	Pan troglodytes
Ap3d1	Rattus norvegicus
APL5	Saccharomyces cerevisiae S288c
apl5	Schizosaccharomyces pombe 972h-

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