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Gene Review

CD69  -  CD69 molecule

Bos taurus

 
 
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High impact information on CD69

  • For these organisms, DNA induced nearly all B cells (including small resting B cells) to up-regulate the activation marker, CD69, and caused many B cells to enter the cell cycle, indicative of polyclonal activation; this effect was not seen after selective methylation of CpG motifs (tested on yeast DNA) [1].
  • Bovine CD69 has the highly conserved amino acid sequences found in the C-type lectin family, suggesting that the conserved residues may be important for conformation and binding to the, as yet unidentified ligand [2].
  • These data suggest that bovine CD69 plays an important role in the activation of lymphocytes [2].
  • Comparison of the bovine CD69 coding sequence reveals 69.4 and 78.2% nucleotide sequence identities with mouse and human CD69, respectively [2].

References

  1. Mitogenicity of DNA from different organisms for murine B cells. Sun, S., Beard, C., Jaenisch, R., Jones, P., Sprent, J. J. Immunol. (1997) [Pubmed]
  2. Cloning of bovine CD69. Ahn, J.S., Hamilton, M.J., Davis, W.C., Park, Y.H. Vet. Immunol. Immunopathol. (2002) [Pubmed]
 
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