Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ARRB2 - arrestin, beta 2

Bos taurus

Komori, N. et al., Goodman, O.B. et al.

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High impact information on ARRB2

Here we report that beta-arrestin and arrestin-3, but not visual arrestin, promote beta2AR internalization and bind with high affinity directly and stoichiometrically to clathrin, the major structural protein of coated pits [1].
Our two-dimensional isoelectric focusing gels using rat spinal cord and heart tissues demonstrate isoelectric heterogeneity of rat beta-arrestin-1, suggesting that beta-arrestin-1 is subject to post-translational modification unlike beta-arrestin-2 [2].

References

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Goodman, O.B., Krupnick, J.G., Santini, F., Gurevich, V.V., Penn, R.B., Gagnon, A.W., Keen, J.H., Benovic, J.L. Nature (1996) [Pubmed]
Differential expression of alternative splice variants of beta-arrestin-1 and -2 in rat central nervous system and peripheral tissues. Komori, N., Cain, S.D., Roch, J.M., Miller, K.E., Matsumoto, H. Eur. J. Neurosci. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

ARRB2	Canis lupus familiaris
arrb2a	Danio rerio
arrb2b	Danio rerio
ARRB2	Homo sapiens
Arrb2	Mus musculus
ARRB2	Pan troglodytes
Arrb2	Rattus norvegicus
arrb2	Xenopus (Silurana) tropicalis

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