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Gene Review

Arrb2  -  arrestin, beta 2

Rattus norvegicus

Synonyms: Arrestin beta-2, Beta-arrestin-2
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Psychiatry related information on Arrb2


High impact information on Arrb2


Biological context of Arrb2


Anatomical context of Arrb2


Associations of Arrb2 with chemical compounds

  • When nimodipine was associated to the chronic opioid treatment, tolerance expression was prevented, and immunoreactivity levels of GRK2, GRK6 and beta-arrestin 2 recovered the control values [6].
  • Chronic treatment with DAMGO or methadone produced internalization of enhanced yellow fluorescent protein-tagged MOR expressed in hippocampal neurons within hours, whereas morphine produced internalization much more slowly, even when accompanied by overexpression of beta-arrestin-2 [10].

Other interactions of Arrb2


Analytical, diagnostic and therapeutic context of Arrb2


  1. Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. Dawson, T.M., Arriza, J.L., Jaworsky, D.E., Borisy, F.F., Attramadal, H., Lefkowitz, R.J., Ronnett, G.V. Science (1993) [Pubmed]
  2. Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. Hennenberg, M., Trebicka, J., Biecker, E., Schepke, M., Sauerbruch, T., Heller, J. Hepatology (2007) [Pubmed]
  3. Activation-dependent conformational changes in {beta}-arrestin 2. Xiao, K., Shenoy, S.K., Nobles, K., Lefkowitz, R.J. J. Biol. Chem. (2004) [Pubmed]
  4. A G protein-coupled receptor kinase induces Xenopus oocyte maturation. Wang, J., Liu, X.J. J. Biol. Chem. (2003) [Pubmed]
  5. Agonist-dependent desensitization of the kappa opioid receptor by G protein receptor kinase and beta-arrestin. Appleyard, S.M., Celver, J., Pineda, V., Kovoor, A., Wayman, G.A., Chavkin, C. J. Biol. Chem. (1999) [Pubmed]
  6. Changes in the expression of G protein-coupled receptor kinases and beta-arrestin 2 in rat brain during opioid tolerance and supersensitivity. Hurlé, M.A. J. Neurochem. (2001) [Pubmed]
  7. The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins. Schmidlin, F., Roosterman, D., Bunnett, N.W. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  8. Beta-adrenergic receptor trafficking by exercise in rat adipocytes: roles of G-protein-coupled receptor kinase-2, beta-arrestin-2, and the ubiquitin-proteasome pathway. Ogasawara, J., Sanpei, M., Rahman, N., Sakurai, T., Kizaki, T., Hitomi, Y., Ohno, H., Izawa, T. FASEB J. (2006) [Pubmed]
  9. Regulation of mu-opioid receptors, G-protein-coupled receptor kinases and beta-arrestin 2 in the rat brain after chronic opioid receptor antagonism. Díaz, A., Pazos, A., Flórez, J., Ayesta, F.J., Santana, V., Hurlé, M.A. Neuroscience (2002) [Pubmed]
  10. Molecular components of tolerance to opiates in single hippocampal neurons. Bushell, T., Endoh, T., Simen, A.A., Ren, D., Bindokas, V.P., Miller, R.J. Mol. Pharmacol. (2002) [Pubmed]
  11. Potential regulatory roles for G protein-coupled receptor kinases and beta-arrestins in gonadotropin-releasing hormone receptor signaling. Neill, J.D., Duck, L.W., Musgrove, L.C., Sellers, J.C. Endocrinology (1998) [Pubmed]
  12. The rat gonadotropin-releasing hormone receptor internalizes via a beta-arrestin-independent, but dynamin-dependent, pathway: addition of a carboxyl-terminal tail confers beta-arrestin dependency. Heding, A., Vrecl, M., Hanyaloglu, A.C., Sellar, R., Taylor, P.L., Eidne, K.A. Endocrinology (2000) [Pubmed]
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