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Gene Review

ARRB2  -  arrestin, beta 2

Homo sapiens

Synonyms: ARB2, ARR2, Arrestin beta-2, BARR2, Beta-arrestin-2, ...
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Disease relevance of ARRB2


Psychiatry related information on ARRB2


High impact information on ARRB2


Biological context of ARRB2


Anatomical context of ARRB2


Associations of ARRB2 with chemical compounds

  • Moreover, stimulation of the angiotensin II type 1A receptor activated JNK3 and triggered the colocalization of beta-arrestin 2 and active JNK3 to intracellular vesicles [6].
  • Our data suggest that in cirrhosis-induced vasodilation, the AT1-R is desensitized by GRK-2 and beta-arrestin-2 and that changed patterns of phosphorylated Ca(2+) sensitizing proteins decrease Ca(2+) sensitivity [19].
  • Here, we report that beta-arrestin 2 stimulates the transcriptional activation of the retinoid RAR and RXR receptors [20].
  • Suppression of beta-arrestin 2 expression using small interfering RNA (siRNA) essentially eliminated AT(1A)R-mediated chemotaxis induced by either Ang II or the S(1)I(4)I(8) Ang II peptide but had no effect on epidermal growth factor (EGF)-induced chemotaxis [21].
  • In the presence of C2 alone, CRIT associates with the adapter protein, beta-arrestin-2, and whether in association with C2 or not, then appears in the perinuclear region, but does not appear to be translocated into the nucleus [22].

Regulatory relationships of ARRB2


Other interactions of ARRB2


Analytical, diagnostic and therapeutic context of ARRB2


  1. G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution. Grange-Midroit, M., García-Sevilla, J.A., Ferrer-Alcón, M., La Harpe, R., Walzer, C., Guimón, J. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  2. An opioid agonist that does not induce micro-opioid receptor--arrestin interactions or receptor internalization. Groer, C.E., Tidgewell, K., Moyer, R.A., Harding, W.W., Rothman, R.B., Prisinzano, T.E., Bohn, L.M. Mol. Pharmacol. (2007) [Pubmed]
  3. Integron-mediated rifampin resistance in Pseudomonas aeruginosa. Tribuddharat, C., Fennewald, M. Antimicrob. Agents Chemother. (1999) [Pubmed]
  4. Decreased morphine analgesia in rat overexpressing beta-arrestin 2 at periaqueductal gray. Jiang, B., Shi, Y., Li, H., Kang, L., Ma, L. Neurosci. Lett. (2006) [Pubmed]
  5. Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts. Ferrer-Alcón, M., La Harpe, R., García-Sevilla, J.A. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  6. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. McDonald, P.H., Chow, C.W., Miller, W.E., Laporte, S.A., Field, M.E., Lin, F.T., Davis, R.J., Lefkowitz, R.J. Science (2000) [Pubmed]
  7. Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Ren, X.R., Reiter, E., Ahn, S., Kim, J., Chen, W., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Azzi, M., Charest, P.G., Angers, S., Rousseau, G., Kohout, T., Bouvier, M., Piñeyro, G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  9. Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Wei, H., Ahn, S., Shenoy, S.K., Karnik, S.S., Hunyady, L., Luttrell, L.M., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Luttrell, L.M., Roudabush, F.L., Choy, E.W., Miller, W.E., Field, M.E., Pierce, K.L., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  11. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation. Estall, J.L., Koehler, J.A., Yusta, B., Drucker, D.J. J. Biol. Chem. (2005) [Pubmed]
  12. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Chen, W., Ren, X.R., Nelson, C.D., Barak, L.S., Chen, J.K., Beachy, P.A., de Sauvage, F., Lefkowitz, R.J. Science (2004) [Pubmed]
  13. beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. Witherow, D.S., Garrison, T.R., Miller, W.E., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  14. Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. Wang, P., Gao, H., Ni, Y., Wang, B., Wu, Y., Ji, L., Qin, L., Ma, L., Pei, G. J. Biol. Chem. (2003) [Pubmed]
  15. Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2. Willoughby, E.A., Collins, M.K. J. Biol. Chem. (2005) [Pubmed]
  16. The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation. El Kouhen, R., Kouhen, O.M., Law, P.Y., Loh, H.H. J. Biol. Chem. (1999) [Pubmed]
  17. Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor. Barak, L.S., Warabi, K., Feng, X., Caron, M.G., Kwatra, M.M. J. Biol. Chem. (1999) [Pubmed]
  18. Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes. DeGraff, J.L., Gagnon, A.W., Benovic, J.L., Orsini, M.J. J. Biol. Chem. (1999) [Pubmed]
  19. Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. Hennenberg, M., Trebicka, J., Biecker, E., Schepke, M., Sauerbruch, T., Heller, J. Hepatology (2007) [Pubmed]
  20. Beta-arrestin 2 modulates the activity of nuclear receptor RAR beta2 through activation of ERK2 kinase. Piu, F., Gauthier, N.K., Wang, F. Oncogene (2006) [Pubmed]
  21. Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Hunton, D.L., Barnes, W.G., Kim, J., Ren, X.R., Violin, J.D., Reiter, E., Milligan, G., Patel, D.D., Lefkowitz, R.J. Mol. Pharmacol. (2005) [Pubmed]
  22. The complement inhibitor, CRIT, undergoes clathrin-dependent endocytosis. Inal, J., Miot, S., Schifferli, J.A. Exp. Cell Res. (2005) [Pubmed]
  23. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L.A., Miller, W.E., Caron, M.G., Barak, L.S., Nusse, R., Lefkowitz, R.J. Science (2003) [Pubmed]
  24. Smoothened signal transduction is promoted by g protein-coupled receptor kinase 2. Meloni, A.R., Fralish, G.B., Kelly, P., Salahpour, A., Chen, J.K., Wechsler-Reya, R.J., Lefkowitz, R.J., Caron, M.G. Mol. Cell. Biol. (2006) [Pubmed]
  25. The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction. Berglund, M.M., Schober, D.A., Statnick, M.A., McDonald, P.H., Gehlert, D.R. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  26. Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. Oakley, R.H., Laporte, S.A., Holt, J.A., Barak, L.S., Caron, M.G. J. Biol. Chem. (2001) [Pubmed]
  27. Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. Wei, H., Ahn, S., Barnes, W.G., Lefkowitz, R.J. J. Biol. Chem. (2004) [Pubmed]
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