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ARRB1  -  arrestin, beta 1

Bos taurus

 
 
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High impact information on ARRB1

  • Here we report that beta-arrestin and arrestin-3, but not visual arrestin, promote beta2AR internalization and bind with high affinity directly and stoichiometrically to clathrin, the major structural protein of coated pits [1].
  • Ultimately the receptor undergoes internalization, and although the molecular mechanism is unclear, receptor phosphorylation and beta-arrestin binding have been implicated in this processs [1].
  • The ability of a system to regulate its responsiveness in the presence of a continuous stimulus, often termed desensitization, has been extensively characterized for the beta2-adrenergic receptor (beta2AR). beta2AR signalling is rapidly attenuated through receptor phosphorylation and subsequent binding of the protein beta-arrestin [1].
  • These results show that beta-arrestin functions as an adaptor in the receptor-mediated endocytosis pathway, and suggest a general mechanism for regulating the trafficking of G-protein-coupled receptors [1].
  • High-affinity binding sites for phosphoinositides in beta-arrestin (arrestin2) and arrestin3 (beta-arrestin2) were identified, and dissimilar effects of phosphoinositide and inositol phosphate on arrestin interactions with clathrin and receptor were characterized [2].
 

Biological context of ARRB1

 

Anatomical context of ARRB1

  • Differential expression of alternative splice variants of beta-arrestin-1 and -2 in rat central nervous system and peripheral tissues [4].
  • These results show that endogenous beta-arrestin participates in cell-free desensitization of agonist-dependent LH/CG R-stimulated AC activity in follicular membranes by interacting directly with the 3i loop of the receptor, thereby preventing Gs activation [7].
 

Associations of ARRB1 with chemical compounds

  • beta-arrestin-dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor [7].
  • The nonvisual arrestins, beta-arrestin and arrestin3, but not visual arrestin, bind specifically to a glutathione S-transferase-clathrin terminal domain fusion protein [8].
  • Although the insertion of a Gly residue (absent in arrestins but present in the putative phosphate-binding site of ataxin-7) disrupts the function of visual arrestin-ataxin-7 chimera, it enhances the function of beta-arrestin-ataxin-7 chimera [9].
 

Other interactions of ARRB1

 

Analytical, diagnostic and therapeutic context of ARRB1

References

  1. Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Goodman, O.B., Krupnick, J.G., Santini, F., Gurevich, V.V., Penn, R.B., Gagnon, A.W., Keen, J.H., Benovic, J.L. Nature (1996) [Pubmed]
  2. Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. Gaidarov, I., Krupnick, J.G., Falck, J.R., Benovic, J.L., Keen, J.H. EMBO J. (1999) [Pubmed]
  3. Interaction of arrestins with intracellular domains of muscarinic and alpha2-adrenergic receptors. Wu, G., Krupnick, J.G., Benovic, J.L., Lanier, S.M. J. Biol. Chem. (1997) [Pubmed]
  4. Differential expression of alternative splice variants of beta-arrestin-1 and -2 in rat central nervous system and peripheral tissues. Komori, N., Cain, S.D., Roch, J.M., Miller, K.E., Matsumoto, H. Eur. J. Neurosci. (1998) [Pubmed]
  5. Beta-arrestin-related proteins in ocular tissues. Nicolas-Léveque, C., Ghedira, I., Faure, J.P., Mirshahi, M. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  6. Cloning of a member of the arrestin family from a human thyroid cDNA library. Rapoport, B., Kaufman, K.D., Chazenbalk, G.D. Mol. Cell. Endocrinol. (1992) [Pubmed]
  7. beta-arrestin-dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor. Mukherjee, S., Palczewski, K., Gurevich, V.V., Hunzicker-Dunn, M. J. Biol. Chem. (1999) [Pubmed]
  8. Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain. Goodman, O.B., Krupnick, J.G., Gurevich, V.V., Benovic, J.L., Keen, J.H. J. Biol. Chem. (1997) [Pubmed]
  9. Conserved phosphoprotein interaction motif is functionally interchangeable between ataxin-7 and arrestins. Mushegian, A.R., Vishnivetskiy, S.A., Gurevich, V.V. Biochemistry (2000) [Pubmed]
  10. Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems. Lohse, M.J., Andexinger, S., Pitcher, J., Trukawinski, S., Codina, J., Faure, J.P., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1992) [Pubmed]
  11. Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of beta-arrestin 1 recruitment. Rasmussen, T.N., Novak, I., Nielsen, S.M. Eur. J. Biochem. (2004) [Pubmed]
 
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