The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

XCR1  -  chemokine (C motif) receptor 1

Homo sapiens

Synonyms: CCXCR1, Chemokine XC receptor 1, G-protein coupled receptor 5, GPR5, Lymphotactin receptor, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on XCR1

  • A similar regulation mechanism could be identified for the Lptn receptor GPR-5 in peripheral T cells [1].
  • By Northern blot analysis, GPR5 mRNA of about 5 kilobases was detected strongly in placenta and weakly in spleen and thymus among various human tissues [2].
  • Up-regulation of XCR1 expression in rheumatoid joints [3].
  • Thus, we have identified a coupling mechanism between the activation of T cells and acquisition of new homing properties, in this case conferred by XCR1 expression [4].
 

Anatomical context of XCR1

  • CONCLUSIONS: We found an up-regulation of XCR1 expression in MNCs from the rheumatoid joint, and detected XCR1 expression in infiltrating MNCs in synovial tissues, as well as increased lymphotactin levels in synovial fluid [3].
  • In addition, we have extended previous analyses of GPR5/XCR1 expression and show that this receptor is expressed in leukocyte cells previously shown to be responsive to lymphotactin [5].
 

Other interactions of XCR1

  • Levels of lymphotactin, the ligand of XCR1, were significantly higher in the joint fluid than those in the paired serum samples (P<0.01) [3].
 

Analytical, diagnostic and therapeutic context of XCR1

References

  1. Expression of the T-cell chemoattractant chemokine lymphotactin in Crohn's disease. Middel, P., Thelen, P., Blaschke, S., Polzien, F., Reich, K., Blaschke, V., Wrede, A., Hummel, K.M., Gunawan, B., Radzun, H.J. Am. J. Pathol. (2001) [Pubmed]
  2. Identification of single C motif-1/lymphotactin receptor XCR1. Yoshida, T., Imai, T., Kakizaki, M., Nishimura, M., Takagi, S., Yoshie, O. J. Biol. Chem. (1998) [Pubmed]
  3. Up-regulation of XCR1 expression in rheumatoid joints. Wang, C.R., Liu, M.F., Huang, Y.H., Chen, H.C. Rheumatology (Oxford, England) (2004) [Pubmed]
  4. Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo. Kurt, R.A., Bauck, M., Harma, S., McCulloch, K., Baher, A., Urba, W.J. Cell. Immunol. (2001) [Pubmed]
  5. Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1. Shan, L., Qiao, X., Oldham, E., Catron, D., Kaminski, H., Lundell, D., Zlotnik, A., Gustafson, E., Hedrick, J.A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities