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Gene Review

XCR1  -  chemokine (C motif) receptor 1

Homo sapiens

Synonyms: CCXCR1, Chemokine XC receptor 1, G-protein coupled receptor 5, GPR5, Lymphotactin receptor, ...
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High impact information on XCR1

  • A similar regulation mechanism could be identified for the Lptn receptor GPR-5 in peripheral T cells [1].
  • By Northern blot analysis, GPR5 mRNA of about 5 kilobases was detected strongly in placenta and weakly in spleen and thymus among various human tissues [2].
  • Up-regulation of XCR1 expression in rheumatoid joints [3].
  • Thus, we have identified a coupling mechanism between the activation of T cells and acquisition of new homing properties, in this case conferred by XCR1 expression [4].

Anatomical context of XCR1

  • CONCLUSIONS: We found an up-regulation of XCR1 expression in MNCs from the rheumatoid joint, and detected XCR1 expression in infiltrating MNCs in synovial tissues, as well as increased lymphotactin levels in synovial fluid [3].
  • In addition, we have extended previous analyses of GPR5/XCR1 expression and show that this receptor is expressed in leukocyte cells previously shown to be responsive to lymphotactin [5].

Other interactions of XCR1

  • Levels of lymphotactin, the ligand of XCR1, were significantly higher in the joint fluid than those in the paired serum samples (P<0.01) [3].

Analytical, diagnostic and therapeutic context of XCR1


  1. Expression of the T-cell chemoattractant chemokine lymphotactin in Crohn's disease. Middel, P., Thelen, P., Blaschke, S., Polzien, F., Reich, K., Blaschke, V., Wrede, A., Hummel, K.M., Gunawan, B., Radzun, H.J. Am. J. Pathol. (2001) [Pubmed]
  2. Identification of single C motif-1/lymphotactin receptor XCR1. Yoshida, T., Imai, T., Kakizaki, M., Nishimura, M., Takagi, S., Yoshie, O. J. Biol. Chem. (1998) [Pubmed]
  3. Up-regulation of XCR1 expression in rheumatoid joints. Wang, C.R., Liu, M.F., Huang, Y.H., Chen, H.C. Rheumatology (Oxford, England) (2004) [Pubmed]
  4. Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo. Kurt, R.A., Bauck, M., Harma, S., McCulloch, K., Baher, A., Urba, W.J. Cell. Immunol. (2001) [Pubmed]
  5. Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1. Shan, L., Qiao, X., Oldham, E., Catron, D., Kaminski, H., Lundell, D., Zlotnik, A., Gustafson, E., Hedrick, J.A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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