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Gene Review:

Xcr1 - chemokine (C motif) receptor 1

Mus musculus

Synonyms: C motif-1/lymphotactin receptor, Ccxcr1, Chemokine XC receptor 1, GPR5, Gpr5, ...

Huang, H. et al., Cairns, C.M. et al., Yoshida, T. et al.

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High impact information on Xcr1

Lymphotactin expression by engineered myeloma cells drives tumor regression: mediation by CD4+ and CD8+ T cells and neutrophils expressing XCR1 receptor [1].
Our data also indicate that mouse neutrophils express the lymphotactin receptor XCR1 and that lymphotactin specifically chemoattracts these cells in vitro [1].
Thus, this study is the first demonstration of a chemotactic effect of Lptn on neutrophils and confirms the association of this effect with expression of the XCR1 receptor on these cells [2].
Neutrophils and B cells express XCR1 receptor and chemotactically respond to lymphotactin [2].
In this study we investigated (i) the chemotactic influences of Lptn on T and B lymphocytes, neutrophils, monocytes, and dendritic cells, and (ii) the expression of the Lptn receptor (XCR1) by these cells, using RT-PCR [2].

Other interactions of Xcr1

Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor [3].

References

Lymphotactin expression by engineered myeloma cells drives tumor regression: mediation by CD4+ and CD8+ T cells and neutrophils expressing XCR1 receptor. Cairns, C.M., Gordon, J.R., Li, F., Baca-Estrada, M.E., Moyana, T., Xiang, J. J. Immunol. (2001) [Pubmed]
Neutrophils and B cells express XCR1 receptor and chemotactically respond to lymphotactin. Huang, H., Li, F., Cairns, C.M., Gordon, J.R., Xiang, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor. Yoshida, T., Izawa, D., Nakayama, T., Nakahara, K., Kakizaki, M., Imai, T., Suzuki, R., Miyasaka, M., Yoshie, O. FEBS Lett. (1999) [Pubmed]

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