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Gene Review:

KCNRG - potassium channel regulator

Homo sapiens

Synonyms: CLLD4, Potassium channel regulator, Potassium channel regulatory protein, Protein CLLD4

Ivanov, D.V. et al., Cho, Y.G. et al.

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Disease relevance of KCNRG

We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene [1].
Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas [2].

High impact information on KCNRG

A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3 [1].
We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14 [1].
Using the patch-clamp technique we determined that KCNRG suppresses K+ channel activity in human prostate cell line LNCaP [1].
Interestingly, the suppressive cell growth activity of the mutant-type KCNRG was significantly lower than that of the wild-type KCNRG [2].
One KCNRG missense mutation, CGT CAT (Arg His) was found at codon 92 within the T1 domain [2].

References

A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. Ivanov, D.V., Tyazhelova, T.V., Lemonnier, L., Kononenko, N., Pestova, A.A., Nikitin, E.A., Prevarskaya, N., Skryma, R., Panchin, Y.V., Yankovsky, N.K., Baranova, A.V. FEBS Lett. (2003) [Pubmed]
Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas. Cho, Y.G., Kim, C.J., Song, J.H., Rhie, D.J., Park, Y.K., Kim, S.Y., Nam, S.W., Yoo, N.J., Lee, J.Y., Park, W.S. Exp. Mol. Med. (2006) [Pubmed]

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