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Gene Review:

GPR19 - G protein-coupled receptor 19

Homo sapiens

Synonyms: GPR-NGA

Montpetit, A. et al., O'Dowd, B.F. et al.

O'Dowd, Nguyen, Lynch, Kolakowski, Thompson, Cheng, Marchese, Ng, Heng, George,

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Disease relevance of GPR19

The delineation of the gene order tel-ETV6-CDKN1B-GPR19-cen excluded GPR19 from the region commonly deleted in childhood ALL, but it could still be the target of genetic alterations found in other cancers [1].

High impact information on GPR19

Physical mapping of the G-protein coupled receptor 19 (GPR19) in the chromosome 12p12.3 region frequently rearranged in cancer cells [1].
Here we report the physical mapping of the G-protein coupled receptor 19 (GPR19) at approximately 40kb from CDKN1B [1].
3. Northern blot analysis revealed expression of GPR19 in peripheral regions, and brain regions significantly overlapping with the D2 receptor gene expression [2].

Analytical, diagnostic and therapeutic context of GPR19

A sequence of the rat orthologue of GPR19 was obtained and in situ hybridization analysis demonstrated a very abundant expression in rat brain [2].

References

Physical mapping of the G-protein coupled receptor 19 (GPR19) in the chromosome 12p12.3 region frequently rearranged in cancer cells. Montpetit, A., Sinnett, D. Hum. Genet. (1999) [Pubmed]
A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. O'Dowd, B.F., Nguyen, T., Lynch, K.R., Kolakowski, L.F., Thompson, M., Cheng, R., Marchese, A., Ng, G., Heng, H.H., George, S.R. FEBS Lett. (1996) [Pubmed]

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