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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GPR22  -  G protein-coupled receptor 22

Homo sapiens

 
 
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High impact information on GPR22

  • This resulted in the isolation of genes GPR21, GPR22 and GPR23 [1].
  • Northern blot analysis revealed expression of GPR20 and GPR22 in several human brain regions while GPR20 expression was detected also in liver [1].
  • Conserved amino acid sequences within the L1 open reading frame of the human papillomavirus (HPV) genome were used as a basis to design two degenerate primers (GP17 and GP18) and one general probe (GPR22) which direct polymerase chain reaction (PCR) amplification and subsequent detection of a 620 to 660 bp DNA fragment [2].
  • As examples of potential uses, we report novel expression sites for four potential therapeutic targets--CCL27, GPR22, GPR113 and GPR128--and as well as a set of thymus-specific genes, including three not previously associated with the thymus [3].

References

  1. Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. O'Dowd, B.F., Nguyen, T., Jung, B.P., Marchese, A., Cheng, R., Heng, H.H., Kolakowski, L.F., Lynch, K.R., George, S.R. Gene (1997) [Pubmed]
  2. Degenerate primers based on highly conserved regions of amino acid sequence in papillomaviruses can be used in a generalized polymerase chain reaction to detect productive human papillomavirus infection. Snijders, P.J., Meijer, C.J., Walboomers, J.M. J. Gen. Virol. (1991) [Pubmed]
  3. Effects of RNA degradation on gene expression analysis of human postmortem tissues. Lee, J., Hever, A., Willhite, D., Zlotnik, A., Hevezi, P. FASEB J. (2005) [Pubmed]
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