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Gene Review:

lef-1 - late expression factor 1

Neodiprion sertifer nucleopolyhedrovirus

Vanarsdall, A.L. et al., Todd, J.W. et al., Mikhailov, V.S. et al.

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Disease relevance of lef-1

Characterization of the role of very late expression factor 1 in baculovirus capsid structure and DNA processing [1].
Very late expression factor 1 (VLF-1) of Autographa californica multiple nucleopolyhedrovirus is a putative tyrosine recombinase and is required for both very late gene expression and budded virus production [1].

High impact information on lef-1

We next examined the effect of the very late expression factor 1 gene (vlf-1), a gene previously identified by analysis of a temperature-sensitive mutant, in the transient expression assay and found that vlf-1 specifically transactivated the two very late promoters but not the two late promoters [2].
BACKGROUND: Baculovirus genomes encode a gene called very late expression factor 1 (VLF-1) that is a member of the integrase (Int) family of proteins [3].

References

Characterization of the role of very late expression factor 1 in baculovirus capsid structure and DNA processing. Vanarsdall, A.L., Okano, K., Rohrmann, G.F. J. Virol. (2006) [Pubmed]
Factors regulating baculovirus late and very late gene expression in transient-expression assays. Todd, J.W., Passarelli, A.L., Lu, A., Miller, L.K. J. Virol. (1996) [Pubmed]
Binding of the baculovirus very late expression factor 1 (VLF-1) to different DNA structures. Mikhailov, V.S., Rohrmann, G.F. BMC Mol. Biol. (2002) [Pubmed]

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