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Gene Review:

tfdDII - ORF29

Ralstonia eutropha JMP134

This record was discontinued.

Laemmli, C.M. et al., Matrubutham, U. et al., Laemmli, C. et al.

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Disease relevance of tfdDII

Ralstonia eutropha JMP134 possesses two sets of similar genes for degradation of chloroaromatic compounds, tfdCDEFB (in short: tfdI cluster) and tfdDII CII EII FII BII (tfdII cluster) [1].
By expressing each ORF in Escherichia coli, we confirmed that tfdD(II) coded for a chloromuconate cycloisomerase, tfdC(II) coded for a chlorocatechol 1, 2-dioxygenase, tfdE(II) coded for a dienelactone hydrolase, tfdF(II) coded for a maleylacetate reductase, and tfdB(II) coded for a chlorophenol hydroxylase [2].

High impact information on tfdDII

An XbaI-PstI fragment, containing the complete ORF, encodes a 32,000-Da protein which binds to the promoter regions upstream from tfdA and tfdDII [3].
None of the tfdDII CII EII FII BII genes appeared to be essential for growth on 2,4-D or on 3-CBA [1].

References

Mutation analysis of the different tfd genes for degradation of chloroaromatic compounds in Ralstonia eutropha JMP134. Laemmli, C., Werlen, C., van der Meer, J.R. Arch. Microbiol. (2004) [Pubmed]
Characterization of a second tfd gene cluster for chlorophenol and chlorocatechol metabolism on plasmid pJP4 in Ralstonia eutropha JMP134(pJP4). Laemmli, C.M., Leveau, J.H., Zehnder, A.J., van der Meer, J.R. J. Bacteriol. (2000) [Pubmed]
Analysis of duplicated gene sequences associated with tfdR and tfdS in Alcaligenes eutrophus JMP134. Matrubutham, U., Harker, A.R. J. Bacteriol. (1994) [Pubmed]

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