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Gene Review

tfdDII  -  ORF29

Ralstonia eutropha JMP134

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Disease relevance of tfdDII

  • Ralstonia eutropha JMP134 possesses two sets of similar genes for degradation of chloroaromatic compounds, tfdCDEFB (in short: tfdI cluster) and tfdDII CII EII FII BII (tfdII cluster) [1].
  • By expressing each ORF in Escherichia coli, we confirmed that tfdD(II) coded for a chloromuconate cycloisomerase, tfdC(II) coded for a chlorocatechol 1, 2-dioxygenase, tfdE(II) coded for a dienelactone hydrolase, tfdF(II) coded for a maleylacetate reductase, and tfdB(II) coded for a chlorophenol hydroxylase [2].

High impact information on tfdDII

  • An XbaI-PstI fragment, containing the complete ORF, encodes a 32,000-Da protein which binds to the promoter regions upstream from tfdA and tfdDII [3].
  • None of the tfdDII CII EII FII BII genes appeared to be essential for growth on 2,4-D or on 3-CBA [1].


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