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Gene Review

SEC14L4  -  SEC14-like 4 (S. cerevisiae)

Homo sapiens

Synonyms: SEC14-like protein 4, TAP3, Tocopherol-associated protein 3, dJ130H16.5
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High impact information on SEC14L4

  • Human thyrotropin-releasing hormone-associated peptide 3 (hTAP-3) in serum [1].
  • These findings indicate the existence of intact hTAP-3 in the human serum and increases in plasma hTAP-3 levels in hyperthyroid patients, suggesting that blood hTAP-3 may be derived from the peripheral organs rather than the hypothalamus [1].
  • The half-life of hTAP-3 in serum was approximately 3.5 min, and the addition of aprotinin and EDTA completely prevented its degradation [1].
  • In hyperthyroid patients, plasma concentrations of hTAP-3 were significantly higher than those in the control group and hypothyroid patients, but no correlation was found between its level and that of thyroid hormone [1].

Analytical, diagnostic and therapeutic context of SEC14L4

  • The dilution curve of hTAP-3 immunoreactivity in the serum paralleled the standard curve of the radioimmunoassay [1].
  • HPLC analysis revealed a single strong immunoreactive peak, which corresponded to the authentic peptide, hTAP-3 [1].


  1. Human thyrotropin-releasing hormone-associated peptide 3 (hTAP-3) in serum. Yamada, M., Konaka, S., Satoh, T., Monden, T., Mori, M. Endocr. J. (1999) [Pubmed]
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