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Gene Review

Sec14l4  -  SEC14-like 4 (S. cerevisiae)

Mus musculus

Synonyms: AI256582, AW536553, SEC14-like protein 4, SPF, TAP
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Disease relevance of Sec14l4


High impact information on Sec14l4

  • Using monoclonal antibodies identifying all gamma/delta and alpha/beta T cell receptors in cytofluorometric analysis, we have compared the composition of intestinal intraepithelial lymphocytes (i-IEL) in euthymic and athymic germ-free (GF) and conventional (SPF) mice [6].
  • Studies on the blood volume of SPF Swiss mice in the steady state led to reevaluation of the distribution of monocytes in the blood compartment [7].
  • After colonizing germ-free mice with commensal microflora without any known pathogens (SPF), <9% of GPX-DKO mice develop tumors in the ileum or the colon [8].
  • Experiments in which the T cell population was held constant revealed that, as APC, spleen cells from AF mice were most often superior to spleen cells from GF mice which were in turn considerably better than a similar population from SPF mice [9].
  • At day 11 of gestation, embryos and their extraembryonic tissues were isolated from the uterus of Him OF1/SPF mice and incubated in Dulbecco's modified Eagle's medium (DMEM) containing L-[35S]methionine [10].

Chemical compound and disease context of Sec14l4

  • Effects of intraperitoneal injection of cyclophosphamide, an immunosuppressant, on the degree of bacterial translocation and morphological changes of Peyer's patches (PP) in the intestine were investigated with antibiotic-decontaminated SPF mice and germfree mice monoassociated with Escherichia coli C25 [11].
  • We have investigated the dose--and administration route-dependent antitumor activity of TT-232 on S-180 sarcoma tumor transplanted to inbred BDF1 mice from SPF breeding [12].
  • To clarify the acute and subchronic inhalation toxicity of tetraethoxysilane [TEOS, Si(OC2H5)4], groups of ten male ICR mice (SPF grade) were exposed to 1000 ppm TEOS for 1,2,4 or 8 h (acute inhalation study), or to 200 ppm of TEOS for 6 h/day, 5 days/week, for 2 or 4 weeks (subchronic inhalation study) [13].
  • In general, amyloidosis in CD-1 mice, was higher in comparison with B6C3F (cross between C57BL/C6 NCRLB and C3H/HEN NCRLB, (bred by Charles River), CFLP strain (hysterectomy derived strain of Swiss origin) and MAGF: TIF (SPF) [14].
  • Ten Swiss albino ICR SPF female mice 110 days old (weight about 30 g) were exposed for 48 hours to a solution of plutonium-238 nitrate (spec. act. 5 MBq/1 m1, pH 2.7) injected in amounts of 0.01 ml into the popliteal area of the right femur, each thus receiving about 500 kBq per 30 g body weight [15].

Biological context of Sec14l4

  • Recent studies comparing pristane-injected conventionally housed BALB/c mice with specific pathogen-free BALB/c mice (SPF) demonstrated a significant reduction in both the incidence of PCT and the T cell infiltration of oil granulomatous tissue in SPF mice [16].
  • The naïve CD4+ T cell subset was functionally distinguished in RF mice versus SPF mice by TCR hyperresponsiveness, pro-inflammatory cytokine production, and increased activation-induced cell death [17].
  • The Ag-specific IgG1 in the serum remained at a low level in both SPF and those gnotobiotic mice groups containing a sufficient number of T cells in the PPs [18].
  • Four injections of cyclophosphamide at a dose of 100 mg/kg inhibited bacterial translocation more than one injection at a dose of 200 mg/kg in SPF mice [11].
  • Allogeneic radiation chimeras induced in SPF mice: Some immunobiological insights into immunologic dysfunctions and instabilities [19].

Anatomical context of Sec14l4

  • Furthermore, 95% of oocytes treated in 0.3 M SPF were successfully enucleated by removing a small amount of cytoplasm adjacent to the projection [20].
  • In SPF mice, the repertoire was polyclonal shortly after birth in the small and large intestine [21].
  • Freshly isolated CD11c+ DC from spleens or MLN of SPF and GF mice expressed similar levels of CD86 and MHCII by FACS analysis [22].
  • Collagenase digestion of slices of lavaged and perfused murine lung from SPF animals yielded, on average, 104 x 10(6) mononuclear cells per gram tissue, including approximately 14% F4/80+ macrophages and 35% lymphocytes [23].
  • SUBJECTS: Established human lung cultured cells and male SPF ICR mice [24].

Associations of Sec14l4 with chemical compounds

  • Our aim was to examine the effect of sesame oil on cisplatin-induced hepatic and renal injuries in mice (8-week-old female SPF C57BL/6) given subcutaneous cisplatin (0, 5, 10, or 20 mg/kg) [25].
  • To test this hypothesis, Swiss mice (ICR/HA) of both sexes, bred and kept in SPF conditions, were dosed daily with TRI in corn oil by gavage (males: 2.4 g/kg, females: 1.8 g/kg) with or without the addition of epichlorohydrin (EPC, 0.8%, w/w), 1,2-epoxybutane (BO, 0,8%), or EPC + BO (0.25% + 0,25%) for 18 months [26].
  • The effectiveness of TT-232 was studied on different rodent tumors transplanted to inbred mice from SPF breeding [27].
  • A 50microm cyst was observed in the brain of one of the 13 prednisolone-treated SPF ICR mice which had been peritoneally inoculated 4 months earlier with the brain homogenate of a serologically N. caninum positive but T. gondii negative cattle [28].
  • The possible hepatocarcinogenic effect of lindane was studied in an 80-week study using 500 NMRI mice (strain Chbi : NMRI (SPF)) [29].

Analytical, diagnostic and therapeutic context of Sec14l4

  • Intraperitoneal injection of LPS upregulated MHCII and CD86 to a similar extent on splenic DC from GF or SPF mice [22].
  • The research summarised in this report suggests that the two UVB-absorbers, o-PABA and 2-EHMC, have different modes of protection against UV radiation-induced immunosuppression, carcinogenesis and histological alterations, that appear to be independent of their SPF values, within experimental limits [30].
  • This ELISA should have worldwide application in testing SPF and commercial chicken flocks for CAA antibodies [31].
  • This HPLC method has been successfully applied for the determination of paclitaxel in pharmacokinetic and biodistribution study in after administration of 50 mg equivalent paclitaxel/kg dose of paclitaxel-loaded polymeric micelle and 20 mg equivalent paclitaxel/kg dose of Taxol to female SPF C57BL/6 mice [32].
  • Although a few SPF mice showed false-positive reactions at a serum dilution of 1:40, further dilution to 1:80 eliminated the non-specific reaction [33].


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  9. Spleen cells from antigen-minimized mice are superior to spleen cells from germ-free and conventional mice in the stimulation of primary in vitro proliferative responses to nominal antigens. Hooper, D.C., Molowitz, E.H., Bos, N.A., Ploplis, V.A., Cebra, J.J. Eur. J. Immunol. (1995) [Pubmed]
  10. Comparison of protein analysis between embryonic and extraembryonic tissues during the 11th day of gestation of the mouse. Baumgartner, B.G., Murach, K.F., Schlegel, E., Praxmayer, C., Illmensee, K. Electrophoresis (1994) [Pubmed]
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  12. In vivo antitumor activity of TT-232 a novel somatostatin analog. Tejeda, M., Gaal, D., Schwab, R.E., Pap, A., Keri, G. Anticancer Res. (1999) [Pubmed]
  13. Acute and subchronic inhalation toxicity of tetraethoxysilane (TEOS) in mice. Nakashima, H., Omae, K., Sakai, T., Yamazaki, K., Sakurai, H. Arch. Toxicol. (1994) [Pubmed]
  14. Survey on spontaneous systemic amyloidosis in aging mice. Majeed, S.K. Arzneimittel-Forschung. (1993) [Pubmed]
  15. Early endosteal bone response to incorporated plutonium-238 in mice. Mohelská, H., Parízek, O., Hyncica, V., Hartlová, E. Journal of hygiene, epidemiology, microbiology, and immunology. (1988) [Pubmed]
  16. Pristane induces an indomethacin inhibitable inflammatory influx of CD4+ T cells and IFN-gamma production in plasmacytoma-susceptible BALB/cAnPt mice. McDonald, A.H., Degrassi, A. Cell. Immunol. (1993) [Pubmed]
  17. Commensal microbiota alter the abundance and TCR responsiveness of splenic naïve CD4+ T lymphocytes. Huang, T., Wei, B., Velazquez, P., Borneman, J., Braun, J. Clin. Immunol. (2005) [Pubmed]
  18. The failure of oral tolerance induction is functionally coupled to the absence of T cells in Peyer's patches under germfree conditions. Maeda, Y., Noda, S., Tanaka, K., Sawamura, S., Aiba, Y., Ishikawa, H., Hasegawa, H., Kawabe, N., Miyasaka, M., Koga, Y. Immunobiology (2001) [Pubmed]
  19. Allogeneic radiation chimeras induced in SPF mice: Some immunobiological insights into immunologic dysfunctions and instabilities. Sado, T., Kamisaku, H. Nippon Ketsueki Gakkai Zasshi (1977) [Pubmed]
  20. Hypertonic medium treatment for localization of nuclear material in bovine metaphase II oocytes. Liu, J.L., Sung, L.Y., Barber, M., Yang, X. Biol. Reprod. (2002) [Pubmed]
  21. The effect of weaning on the clonality of alphabeta T-cell receptor T cells in the intestine of GF and SPF mice. Probert, C.S., Williams, A.M., Stepankova, R., Tlaskalova-Hogenova, H., Phillips, A., Bland, P.W. Dev. Comp. Immunol. (2007) [Pubmed]
  22. Dendritic cells in germ-free and specific pathogen-free mice have similar phenotypes and in vitro antigen presenting function. Walton, K.L., He, J., Kelsall, B.L., Sartor, R.B., Fisher, N.C. Immunol. Lett. (2006) [Pubmed]
  23. Functional studies on macrophage populations in the airways and the lung wall of SPF mice in the steady-state and during respiratory virus infection. Bilyk, N., Mackenzie, J.S., Papadimitriou, J.M., Holt, P.G. Immunology (1988) [Pubmed]
  24. Propofol improves recovery from paraquat acute toxicity in vitro and in vivo. Ariyama, J., Shimada, H., Aono, M., Tsuchida, H., Hirai, K.I. Intensive care medicine. (2000) [Pubmed]
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  27. Influence of various administration routes on the antitumor efficacy ofTT-232, a novel somatostatin analog. Tejeda, M., Gaal, D., Schwab, R.E., Pap, A., Szúts, T., Keri, G. Anticancer Res. (2000) [Pubmed]
  28. Serological survey and first finding of Neospora caninum in Taiwan, and the detection of its antibodies in various body fluids of cattle. Ooi, H.K., Huang, C.C., Yang, C.H., Lee, S.H. Vet. Parasitol. (2000) [Pubmed]
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  30. The effects of two UVB radiation-absorbing sunscreens on UV radiation-induced carcinogenesis, suppression of the contact hypersensitivity response and histological changes in the hairless mouse. Kerr, C. Mutat. Res. (1998) [Pubmed]
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  32. Sensitive HPLC method for quantitation of paclitaxel (Genexol in biological samples with application to preclinical pharmacokinetics and biodistribution. Kim, S.C., Yu, J., Lee, J.W., Park, E.S., Chi, S.C. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  33. Detection of antibodies to Sendai virus in mouse sera by enzyme-linked immunosorbent assay (ELISA). Suzuki, E., Noguchi, A., Takeda, H. Jpn. J. Med. Sci. Biol. (1987) [Pubmed]
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