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Gene Review:

NSMCE2 - non-SMC element 2, MMS21 homolog (S....

Homo sapiens

Synonyms: C8orf36, E3 SUMO-protein ligase NSE2, FLJ32440, MMS21, MMS21 homolog, ...

Potts, P.R. et al., McDonald, W.H. et al.

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Disease relevance of NSMCE2

Ectopic expression of wild-type hMMS21, but not its ligase-inactive mutant, rescues this hypersensitivity of hMMS21-RNAi cells [1].

High impact information on NSMCE2

Our findings suggest that the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells [1].
Depletion of hMMS21 by RNA interference (RNAi) sensitizes HeLa cells toward DNA damage-induced apoptosis [1].
Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex [2].
Loss of Nse1 and Nse2 function leads to strikingly similar terminal phenotypes to those observed for Smc5-6 inactivation [2].
In addition, cells expressing hypomorphic alleles of Nse1 and Nse2 are, like Smc5-6 mutants, hypersensitive to DNA damage [2].

References

Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Potts, P.R., Yu, H. Mol. Cell. Biol. (2005) [Pubmed]
Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex. McDonald, W.H., Pavlova, Y., Yates, J.R., Boddy, M.N. J. Biol. Chem. (2003) [Pubmed]

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