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Gene Review

NSMCE2  -  non-SMC element 2, MMS21 homolog (S....

Homo sapiens

Synonyms: C8orf36, E3 SUMO-protein ligase NSE2, FLJ32440, MMS21, MMS21 homolog, ...
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Disease relevance of NSMCE2

  • Ectopic expression of wild-type hMMS21, but not its ligase-inactive mutant, rescues this hypersensitivity of hMMS21-RNAi cells [1].

High impact information on NSMCE2


  1. Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Potts, P.R., Yu, H. Mol. Cell. Biol. (2005) [Pubmed]
  2. Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex. McDonald, W.H., Pavlova, Y., Yates, J.R., Boddy, M.N. J. Biol. Chem. (2003) [Pubmed]
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