Gene Review:
mecA - penicillin-binding protein 2 prime
Staphylococcus aureus subsp. aureus MRSA252
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Disease relevance of mecA
- Genetic background affects stability of mecA in Staphylococcus aureus [1].
High impact information on mecA
- The staphylococcal methicillin resistance determinant, mecA, resides on a mobile genetic element, staphylococcus chromosomal cassette mec (SCCmec) [1].
- In this study, we investigate the potential role of the host chromosome in the transformability and expression of mecA in 103 naturally occurring methicillin-susceptible S. aureus clinical isolates [1].
- We introduced mecA expressed on the low-copy-number plasmid pYK20 into each MSSA strain and assayed the phenotype of resistance to nafcillin by population analysis to assess the relationship between the stability of mecA expression and genetic background [1].
References
- Genetic background affects stability of mecA in Staphylococcus aureus. Katayama, Y., Robinson, D.A., Enright, M.C., Chambers, H.F. J. Clin. Microbiol. (2005) [Pubmed]
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