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Chemical Compound Review

nafcillin     (2R,5R,6S)-6-[(2- ethoxynaphthalen-1...

Synonyms: Nafcilina, Nallpen, Nafcilline, Naphcillin, Unipen, ...
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Disease relevance of nafcillin


High impact information on nafcillin

  • The combinations of gentamicin sulfate, nafcillin sodium, or vancomycin hydrochloride with rifampin prevented the emergence of rifampin resistance in vitro and promoted enhanced killing when compared with either antibiotic alone [5].
  • Addition of nafcillin to cultures of this strain caused a rapid increase in the amount of this PBP in cell membranes [2].
  • Slime-producing CNS were recovered from PVC catheters after overnight incubation in cidal concentrations (greater than 4.0 micrograms/ml) of nafcillin (average 350 colony-forming units per 1 cm) [6].
  • This study assessed the effect of cirrhosis and extrahepatic biliary obstruction in man on the pharmacokinetics of nafcillin [3].
  • His prothrombin time ranged between 14 and 17 s (control, 12 s) despite an increase in his warfarin dosage to 25 mg/d. Pharmacokinetic studies showed that the decreased hypoprothrombinemic effect of warfarin was most likely due to rapid metabolism of the anticoagulant induced by nafcillin [7].

Chemical compound and disease context of nafcillin


Biological context of nafcillin


Anatomical context of nafcillin


Associations of nafcillin with other chemical compounds


Gene context of nafcillin


Analytical, diagnostic and therapeutic context of nafcillin


  1. Neutropenia probably resulting from nafcillin. Sandberg, M., Tuazon, C.U., Sheagren, J.N. JAMA (1975) [Pubmed]
  2. Increased amounts of a novel penicillin-binding protein in a strain of methicillin-resistant Staphylococcus aureus exposed to nafcillin. Chambers, H.F., Hartman, B.J., Tomasz, A. J. Clin. Invest. (1985) [Pubmed]
  3. Disposition of nafcillin in patients with cirrhosis and extrahepatic biliary obstruction. Marshall, J.P., Salt, W.B., Elam, R.O., Wilkinson, G.R., Schenker, S. Gastroenterology (1977) [Pubmed]
  4. Nafcillin concentration in cerebrospinal fluid during treatment of staphylococcal infections. Kane, J.G., Parker, R.H., Jordan, G.W., Hoeprich, P.D. Ann. Intern. Med. (1977) [Pubmed]
  5. Rifampin therapy of Staphylococcus epidermidis. Use in infections from indwelling artificial devices. Archer, G.L., Tenenbaum, M.J., Haywood, H.B. JAMA (1978) [Pubmed]
  6. Influence of bacterial adherence to intravascular catheters on in-vitro antibiotic susceptibility. Sheth, N.K., Franson, T.R., Sohnle, P.G. Lancet (1985) [Pubmed]
  7. Warfarin resistance with nafcillin therapy. Qureshi, G.D., Reinders, T.P., Somori, G.J., Evans, H.J. Ann. Intern. Med. (1984) [Pubmed]
  8. Neutropenia after consecutive treatment courses with nafcillin and piperacillin. Wilson, C., Greenhood, G., Remington, J.S., Vosti, K.L. Lancet (1979) [Pubmed]
  9. Toxic shock syndrome: management and long-term sequelae. Chesney, P.J., Crass, B.A., Polyak, M.B., Wand, P.J., Warner, T.F., Vergeront, J.M., Davis, J.P., Tofte, R.W., Chesney, R.W., Bergdoll, M.S. Ann. Intern. Med. (1982) [Pubmed]
  10. Tolerant Staphylococcus aureus causing vertebral osteomyelitis. Musher, D.M., Fletcher, T. Arch. Intern. Med. (1982) [Pubmed]
  11. Efficacy of ticarcillin-clavulanic acid for treatment of experimental Staphylococcus aureus endocarditis in rats. Catherall, E.J., Gillon, V., Hurn, S., Irwin, R., Mizen, L. Antimicrob. Agents Chemother. (1992) [Pubmed]
  12. In vitro antimicrobial activity of aztreonam alone and in combination against bacterial isolates from pediatric patients. Stutman, H.R., Welch, D.F., Scribner, R.K., Marks, M.I. Antimicrob. Agents Chemother. (1984) [Pubmed]
  13. Renal failure, hemodialysis, and nafcillin kinetics. Rudnick, M., Morrison, G., Walker, B., Singer, I. Clin. Pharmacol. Ther. (1976) [Pubmed]
  14. Penetrance of nafcillin into human ventricular fluid: correlation with ventricular pleocytosis and glucose levels. Yogev, R., Schultz, W.E., Rosenman, S.B. Antimicrob. Agents Chemother. (1981) [Pubmed]
  15. Genetic background affects stability of mecA in Staphylococcus aureus. Katayama, Y., Robinson, D.A., Enright, M.C., Chambers, H.F. J. Clin. Microbiol. (2005) [Pubmed]
  16. Impaired platelet function associated with parenteral nafcillin. Jeter, E.K., Scott, A., Kizer, J., Lazarchick, J. Ann. Clin. Lab. Sci. (1990) [Pubmed]
  17. Retrospective evaluation of therapies for Staphylococcus aureus endocarditis. Gentry, C.A., Rodvold, K.A., Novak, R.M., Hershow, R.C., Naderer, O.J. Pharmacotherapy (1997) [Pubmed]
  18. Antibiotic penetration into normal and inflamed tissues as reflected by peripheral lymph. Roberts, T.L., Futrell, J.W., Sande, M.A. Ann. Surg. (1979) [Pubmed]
  19. Teicoplanin versus nafcillin and vancomycin in the treatment of experimental endocarditis caused by methicillin-susceptible or -resistant Staphylococcus aureus. Chambers, H.F., Sande, M.A. Antimicrob. Agents Chemother. (1984) [Pubmed]
  20. Synergistic action of nafcillin and ampicillin against ampicillin-resistant Haemophilus influenzae type b bacteremia and meningitis in infant rats. Yogev, R., Kabat, W.J. Antimicrob. Agents Chemother. (1980) [Pubmed]
  21. Successful therapy of experimental endocarditis caused by vancomycin-resistant Staphylococcus aureus with a combination of vancomycin and beta-lactam antibiotics. Fox, P.M., Lampen, R.J., Stumpf, K.S., Archer, G.L., Climo, M.W. Antimicrob. Agents Chemother. (2006) [Pubmed]
  22. Comparative evaluation of A-56619, A-56620, and nafcillin in the treatment of experimental Staphylococcus aureus osteomyelitis. Mader, J.T., Morrison, L.T., Adams, K.R. Antimicrob. Agents Chemother. (1987) [Pubmed]
  23. Cefotaxime vs nafcillin and tobramycin for the treatment of serious infection. Comparative cost-effectiveness. Moore, R.D., Smith, C.R., Holloway, J.J., Lietman, P.S. Arch. Intern. Med. (1986) [Pubmed]
  24. Comparative in vitro activity of nafcillin, oxacillin, and methicillin in combination with gentamicin and tobramycin against enterococci. Watanakunakorn, C., Glotzbecker, C. Antimicrob. Agents Chemother. (1977) [Pubmed]
  25. Prediction of the concentration of penicillins in ascitic fluid from serum kinetics and protein binding of the antibiotics in serum and ascitic fluid of dogs. Gerding, D.N., Peterson, L.R., Salomonson, J.K., Hall, W.H., Schierl, E.A. J. Infect. Dis. (1978) [Pubmed]
  26. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Tan, A.K., Fink, A.L. Biochem. J. (1992) [Pubmed]
  27. Transposon Tn916 mutagenesis in Bacillus anthracis. Ivins, B.E., Welkos, S.L., Knudson, G.B., Leblanc, D.J. Infect. Immun. (1988) [Pubmed]
  28. Kinetic and structural characterization of reversibly inactivated beta-lactamase. Fink, A.L., Behner, K.M., Tan, A.K. Biochemistry (1987) [Pubmed]
  29. Efficacy of ampicillin plus a beta-lactamase inhibitor (CP-45,899) in experimental endocarditis due to Staphylococcus aureus. Washburn, R.G., Durack, D.T. J. Infect. Dis. (1981) [Pubmed]
  30. Extracellular proteases increase tolerance of Bacillus subtilis to nafcillin. Jolliffe, L.K., Doyle, R.J., Streips, U.N. Antimicrob. Agents Chemother. (1982) [Pubmed]
  31. Extraction of antibiotics from the circulation by liver and kidney: effect of probenecid. Barza, M., Brusch, J., Bergeron, M.G., Kemmotsu, O., Weinstein, L. J. Infect. Dis. (1975) [Pubmed]
  32. New rapid assay for nafcillin in serum by spectrofluorometry. Lichtenwalner, D.M., Suh, B., Lorber, B., Sugar, A.M. Antimicrob. Agents Chemother. (1979) [Pubmed]
  33. Potentiation of cyclosporine nephrotoxicity by nafcillin in lung transplant recipients. Jahansouz, F., Kriett, J.M., Smith, C.M., Jamieson, S.W. Transplantation (1993) [Pubmed]
  34. Laboratory tests for defining bactericidal activity as predictors of antibiotic efficacy in the treatment of endocarditis due to Staphylococcus aureus in rabbits. Fass, R.J. J. Infect. Dis. (1984) [Pubmed]
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