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Gene Review

mcm5  -  minichromosome maintenance complex...

Danio rerio

Synonyms: SO:0000704
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High impact information on mcm5

  • Here, we present positional cloning of a zebrafish mcm5 mutation and characterization of its retina phenotype [1].
  • In the retina, mcm5 expression correlates closely with the pattern of cell proliferation [1].
  • By the third day of development, mcm5 is down-regulated in differentiated cells but is maintained in regions containing retinal stem cells [1].


  1. Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis. Ryu, S., Holzschuh, J., Erhardt, S., Ettl, A.K., Driever, W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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