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Gene Review

Abca5  -  ATP-binding cassette, subfamily A (ABC1),...

Rattus norvegicus

Synonyms: ATP-binding cassette sub-family A member 5
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Disease relevance of Abca5


High impact information on Abca5

  • Up-regulation of Abca5 mRNA expression during culture of primary rat hepatocytes suggests that hepatocyte cultures should provide a basis for investigation of Abca5 gene regulation and elucidation of Abca5 function [2].
  • Northern blot analyses revealed expression of ABCA5 or Abca5 mRNA in several tissues, but particularly high Abca5 mRNA expression was observed in rat testis [2].


  1. ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms. Kubo, Y., Sekiya, S., Ohigashi, M., Takenaka, C., Tamura, K., Nada, S., Nishi, T., Yamamoto, A., Yamaguchi, A. Mol. Cell. Biol. (2005) [Pubmed]
  2. Cloning of human and rat ABCA5/Abca5 and detection of a human splice variant. Petry, F., Kotthaus, A., Hirsch-Ernst, K.I. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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