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Gene Review:

Wnk4 - WNK lysine deficient protein kinase 4

Rattus norvegicus

Synonyms: Ac2-059, Prkwnk4, Protein kinase lysine-deficient 4, Protein kinase with no lysine 4, Serine/threonine-protein kinase WNK4

Monti, J. et al.

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Disease relevance of Wnk4

The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10 [1].

High impact information on Wnk4

In this report, we describe the confirmation of the blood pressure QTL on rat chromosome 10 by congenic approaches, spanning the Wnk4 locus [1].
Additionally, we excluded a secondary effect of blood pressure on the transcriptional regulation of Wnk4 [1].
The hypothesis has been advanced that molecular variants of this gene might contribute to common polygenic forms of hypertension, since Wnk4 is located in a region of conserved synteny that demonstrates an overlap between quantitative trait loci for primary hypertension in humans and rats [1].

Biological context of Wnk4

Wnk4, a gene previously identified to cause pseudohypoaldosteronism type II, a rare mendelian form of arterial hypertension, is located on human chromosome 17 [1].

References

The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10. Monti, J., Zimdahl, H., Schulz, H., Plehm, R., Ganten, D., Hübner, N. Hypertension (2003) [Pubmed]

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