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Gene Review: 

IGKV2D-24  -  immunoglobulin kappa variable 2D-24 (non...

Homo sapiens

Synonyms: A7, IGKV2D24
 
 
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Disease relevance of IGKV2D-24

 

High impact information on IGKV2D-24

  • Both A7 and 7C5 had a lysine at the V(H)-D junction, whereas 1A2 had a threonine [2].
  • Neocarzinostatin (NCS) was bound covalently to human/mouse chimeric Fab fragments of MAb A7 (chA7Fab) directed against human pancreatic carcinoma [3].
  • Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1 [4].
 

Analytical, diagnostic and therapeutic context of IGKV2D-24

  • Nucleic acid sequence analysis of three MAbs (A7, 1A2, and 7C5) revealed that they use two different V(H)3 genes (A7 and 1A2 both use V3-15) and three different V(kappa) gene segments [2].

References

  1. Clinical application of monoclonal antibody-drug conjugates for immunotargeting chemotherapy of colorectal carcinoma. Takahashi, T., Yamaguchi, T., Kitamura, K., Suzuyama, H., Honda, M., Yokota, T., Kotanagi, H., Takahashi, M., Hashimoto, Y. Cancer (1988) [Pubmed]
  2. Structure-function relationships for human antibodies to pneumococcal capsular polysaccharide from transgenic mice with human immunoglobulin Loci. Chang, Q., Zhong, Z., Lees, A., Pekna, M., Pirofski, L. Infect. Immun. (2002) [Pubmed]
  3. Effects of neocarzinostatin-chimeric Fab conjugates on the growth of human pancreatic carcinoma xenografts. Otsuji, E., Yamaguchi, T., Tsuruta, H., Yata, Y., Nishi, H., Okamoto, K., Taniguchi, K., Kato, M., Kotani, T., Kitamura, K., Takahashi, T. Br. J. Cancer (1996) [Pubmed]
  4. Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1. McIlhatton, M.A., Bremner, P., McMullin, M.F., Maxwell, A.P., Winter, P.C., Lappin, T.R. Biochim. Biophys. Acta (1998) [Pubmed]
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