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Gene Review

TMEM176B  -  transmembrane protein 176B

Homo sapiens

Synonyms: LR8, Protein LR8, Transmembrane protein 176B
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Disease relevance of TMEM176B

  • Here we have chosen the multifunctional chicken oocyte receptor for yolk deposition (termed LR8), and the pan-receptor ligand, receptor associated protein (RAP), as model systems to characterize a minireceptor using the phage display approach [1].

High impact information on TMEM176B

  • Selected oocytes gain access to yolk precursors, and LR8 binds, internalizes, and deposits the major yolk components in the ratio of their relative abundance in the accessible pool [2].
  • C3 is transported into oocytes by LR8-mediated endocytosis [2].
  • Full length cloning of GS188 identified it as a family member of LR8 that was reported to express predominantly in fibroblasts [3].
  • We have identified the murine Clast1/LR8 gene by subtraction of cDNA derived from CD40 ligand-activated and naive B cells [4].


  1. A minimal binding domain of the low density lipoprotein receptor family. Bajari, T.M., Lindstedt, K.A., Riepl, M., Mirsky, V.M., Nimpf, J., Wolfbeis, O.S., Dresel, H.A., Bautz, E.K., Schneider, W.J. Biol. Chem. (1998) [Pubmed]
  2. Receptor-mediated transport and deposition of complement component C3 into developing chicken oocytes. Recheis, B., Rumpler, H., Schneider, W.J., Nimpf, J. Cell. Mol. Life Sci. (2005) [Pubmed]
  3. Gene expression profile of renal proximal tubules regulated by proteinuria. Nakajima, H., Takenaka, M., Kaimori, J.Y., Nagasawa, Y., Kosugi, A., Kawamoto, S., Imai, E., Hori, M., Okubo, K. Kidney Int. (2002) [Pubmed]
  4. Role of Clast1 in development of cerebellar granule cells. Maeda, Y., Fujimura, L., O-Wang, J., Hatano, M., Sakamoto, A., Arima, M., Ebara, M., Ino, H., Yamashita, T., Saisho, H., Tokuhisa, T. Brain Res. (2006) [Pubmed]
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