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Gene Review

SLC6A16  -  solute carrier family 6, member 16

Homo sapiens

Synonyms: NT5, NTT5, Orphan sodium-and chloride-dependent neurotransmitter transporter NTT5, Solute carrier family 6 member 16
 
 
 
 
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High impact information on SLC6A16

  • Radiation hybrid mapping located the human v7-3 and NTT5 genes on chromosomes 12q21.3-q21.4 and 19q13.1-q13.4, respectively [1].
  • The amino acid sequences of human v7-3 and NTT5 are greater than 50% similar to other known orphan neurotransmitter transporters and also show sequence similarity to the human serotonin and dopamine transporters [1].
  • In contrast, NTT5 mRNA was highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate [1].
  • Transient transfection with epitope-tagged transporter constructs demonstrated v7-3 to be expressed at the cell surface, whereas NTT5 was predominantly intracellular, suggestive of a vesicular location [1].

References

  1. Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family. Farmer, M.K., Robbins, M.J., Medhurst, A.D., Campbell, D.A., Ellington, K., Duckworth, M., Brown, A.M., Middlemiss, D.N., Price, G.W., Pangalos, M.N. Genomics (2000) [Pubmed]
 
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