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Gene Review

Myh13  -  myosin, heavy chain 13, skeletal muscle

Rattus norvegicus

Synonyms: MHCEO, MyHC
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High impact information on Myh13

  • VIVIT was found to block the expression of slow myosin heavy chain (MyHC-slow) induced by slow motor neuron activity in regenerating slow soleus muscle and to inhibit the expression of MyHC-slow transcripts and the activity of a MyHC-slow promoter in adult soleus [1].
  • RNase protection assays for the embryonic (Myh3) and extraocular (Myh13) MyHC isoform mRNAs were also performed [2].
  • The contralateral muscles were used to count muscle spindles and spindle fibers (ATPase staining) and to identify MyHC isoforms by immunostaining [3].
  • Importantly, this combined neurotrophin regimen also prevented the disappearance of muscle fibers that express myosin heavy chain IIB (MyHC IIB) in both EDL and TA muscles 3 mo after neonatal sciatic nerve crush [4].
  • We examined the functional role of distinct muscle-CAT (MCAT) elements during non-weight-bearing (NWB) regulation of a wild-type 293-base pair beta-myosin heavy chain (beta MyHC) transgene [5].

Anatomical context of Myh13

  • All single soleus muscle fibres from hyperthyroid rats co-expressed types I and IIA myosin heavy chains (type I/IIA fibres) or type I, IIA and IIX myosin heavy chains (type I/IIAX fibres), while only type I MyHC fibres were isolated from the controls [6].


  1. NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching. McCullagh, K.J., Calabria, E., Pallafacchina, G., Ciciliot, S., Serrano, A.L., Argentini, C., Kalhovde, J.M., Lømo, T., Schiaffino, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. The development of longitudinal variation of Myosin isoforms in the orbital fibers of extraocular muscles of rats. Rubinstein, N.A., Porter, J.D., Hoh, J.F. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  3. Adaptation of rat soleus muscle spindles after 21 days of hindlimb unloading. Rosant, C., Nagel, M.D., Pérot, C. Exp. Neurol. (2006) [Pubmed]
  4. BDNF rescues myosin heavy chain IIB muscle fibers after neonatal nerve injury. Mousavi, K., Parry, D.J., Jasmin, B.J. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  5. Divergence in species and regulatory role of beta -myosin heavy chain proximal promoter muscle-CAT elements. Tsika, R.W., McCarthy, J., Karasseva, N., Ou, Y., Tsika, G.L. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  6. Contractility and myosin isoform compositions of skeletal muscles and muscle cells from rats treated with thyroid hormone for 0, 4 and 8 weeks. Li, X., Larsson, L. J. Muscle Res. Cell. Motil. (1997) [Pubmed]
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