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Gene Review

Pcsk7  -  proprotein convertase subtilisin/kexin type 7

Rattus norvegicus

Synonyms: PC7, Pc7, Prohormone convertase 7, Proprotein convertase 7, Proprotein convertase subtilisin/kexin type 7, ...
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Disease relevance of Pcsk7

  • Biochemical and enzymatic characterization of the novel proprotein convertase rat PC7 (rPC7) was carried out using vaccinia virus recombinants overexpressed in mammalian BSC40 cells [1].

High impact information on Pcsk7

  • By screening rat spleen and PC12 cell lambda gt11 cDNA libraries, we obtained a composite 3.5-kb full-length cDNA sequence of rPC7 [2].
  • Thus, this study establishes that rPC7 is an enzymatically functional subtilisin/kexin-like serine proteinase with a cleavage specificity resembling that of hfurin [1].

Analytical, diagnostic and therapeutic context of Pcsk7

  • Northern blot analyses demonstrated a widespread expression with the richest source of rPC7 mRNA being the colon and lymphoid-associated tissues [2].


  1. In vitro characterization of the novel proprotein convertase PC7. Munzer, J.S., Basak, A., Zhong, M., Mamarbachi, A., Hamelin, J., Savaria, D., Lazure, C., Hendy, G.N., Benjannet, S., Chrétien, M., Seidah, N.G. J. Biol. Chem. (1997) [Pubmed]
  2. cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Seidah, N.G., Hamelin, J., Mamarbachi, M., Dong, W., Tardos, H., Mbikay, M., Chretien, M., Day, R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
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