High impact information on YPEL1

• Amino acid sequences of these 100 YPEL proteins were extremely similar and a consensus sequence of C-X(2)-C-X(19)-G-X(3)-L-X(5)-N-X(13)-G-X(8)-C-X(2)-C-X(4)-GWXY-X(10)-K-X(6)-E was established for all the YPEL family proteins without exception [1].
• The subcellular localization of YPEL proteins in association with centrosome or mitotic spindle suggests a novel function involved in the cell division [1].
• In addition, human YPEL1 localizes to chromosome 22q11.2, a region associated with a number of syndromes involving malformation of the craniofacial complex [2].
• Ypel1: a novel nuclear protein that induces an epithelial-like morphology in fibroblasts [2].
• Ypel1 is expressed in the ventral half of early embryos including the branchial arches from which the face derives [2].

Biological context of YPEL1

• Ypel1 localizes to the nucleus, and transfection into fibroblasts induces an epithelial-like transition, which is accompanied by alterations to the cytoskeleton and cell adhesion machinery [2].
• These YPEL genes showed high homology (43.8-96.6%) at amino acid sequence level among them [1].

Analytical, diagnostic and therapeutic context of YPEL1

• Sequence analysis of this gene, known as Ypel1, demonstrates a striking level of amino acid conservation between vertebrates and invertebrates but no significant homology with any other characterized genes [2].

References