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Gene Review

ZDHHC1  -  zinc finger, DHHC-type containing 1

Homo sapiens

Synonyms: C16orf1, DHHC domain-containing cysteine-rich protein 1, DHHC-1, HSU90653, ZNF377, ...
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High impact information on ZDHHC1

  • Numerous genes encoding DHHC domain proteins are found in all eukaryotic genome databases [1].
  • Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian cells [2].
  • Increasing evidence indicates that DHHC cysteine-rich domain-containing proteins (DHHC proteins) are protein acyltransferases [3].
  • Most DHHC proteins are localized in the ER and/or Golgi, with a few localized in the plasma membrane and one in the yeast vacuole [3].


  1. Protein palmitoylation by a family of DHHC protein S-acyltransferases. Mitchell, D.A., Vasudevan, A., Linder, M.E., Deschenes, R.J. J. Lipid Res. (2006) [Pubmed]
  2. Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian cells. Fukata, Y., Iwanaga, T., Fukata, M. Methods (2006) [Pubmed]
  3. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno, Y., Kihara, A., Sano, T., Igarashi, Y. Biochim. Biophys. Acta (2006) [Pubmed]
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