The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

NENF  -  neudesin neurotrophic factor

Homo sapiens

Synonyms: CIR2, Cell immortalization-related protein 2, Neudesin, Neuron-derived neurotrophic factor, SCIRP10, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of NENF

  • The activity of neudesin was inhibited by the inhibitor pertussis toxin for Gi/Go-protein but not by inhibitors for receptor tyrosine kinases [1].
 

High impact information on NENF

  • A 5-6-fold elevation in CIR1/CROC1 expression and a 2-3-fold elevation in CIR2 expression were observed in SV40-transformed human embryonic kidney cells immediately following proliferative crisis, suggesting a potential role for these genes in immortalization [2].
  • The neudesin protein produced in cultured cells was secreted efficiently into the culture medium [1].
  • The human neudesin gene was mapped to chromosome 1p33 [1].
  • Mouse neudesin mRNA was expressed in neurons but not glial cells of the brain [1].
  • Mouse neudesin mRNA was expressed abundantly in the developing brain and spinal cord in embryos, but was expressed widely in postnatal tissues including brain, heart, lung, and kidney [1].
 

Anatomical context of NENF

  • The resulting CIR gene, termed F39scFv/CIR-2, was transfected into human T cells [3].
 

Other interactions of NENF

  • Two transcripts, denoted CIR1 and CIR2, were identified which were up-regulated in immortal cells [2].
 

Analytical, diagnostic and therapeutic context of NENF

References

  1. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. Kimura, I., Yoshioka, M., Konishi, M., Miyake, A., Itoh, N. J. Neurosci. Res. (2005) [Pubmed]
  2. Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. Ma, L., Broomfield, S., Lavery, C., Lin, S.L., Xiao, W., Bacchetti, S. Oncogene (1998) [Pubmed]
  3. Targeting of T cells to CEA-expressing tumor cells by chimeric immune receptors with a highly specific single-chain anti-CEA activity. Arakawa, F., Shibaguchi, H., Xu, Z., Kuroki, M. Anticancer Res. (2002) [Pubmed]
 
WikiGenes - Universities