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Gene Review

NENF  -  neudesin neurotrophic factor

Homo sapiens

Synonyms: CIR2, Cell immortalization-related protein 2, Neudesin, Neuron-derived neurotrophic factor, SCIRP10, ...
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Disease relevance of NENF

  • The activity of neudesin was inhibited by the inhibitor pertussis toxin for Gi/Go-protein but not by inhibitors for receptor tyrosine kinases [1].

High impact information on NENF

  • A 5-6-fold elevation in CIR1/CROC1 expression and a 2-3-fold elevation in CIR2 expression were observed in SV40-transformed human embryonic kidney cells immediately following proliferative crisis, suggesting a potential role for these genes in immortalization [2].
  • The neudesin protein produced in cultured cells was secreted efficiently into the culture medium [1].
  • The human neudesin gene was mapped to chromosome 1p33 [1].
  • Mouse neudesin mRNA was expressed in neurons but not glial cells of the brain [1].
  • Mouse neudesin mRNA was expressed abundantly in the developing brain and spinal cord in embryos, but was expressed widely in postnatal tissues including brain, heart, lung, and kidney [1].

Anatomical context of NENF

  • The resulting CIR gene, termed F39scFv/CIR-2, was transfected into human T cells [3].

Other interactions of NENF

  • Two transcripts, denoted CIR1 and CIR2, were identified which were up-regulated in immortal cells [2].

Analytical, diagnostic and therapeutic context of NENF


  1. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. Kimura, I., Yoshioka, M., Konishi, M., Miyake, A., Itoh, N. J. Neurosci. Res. (2005) [Pubmed]
  2. Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. Ma, L., Broomfield, S., Lavery, C., Lin, S.L., Xiao, W., Bacchetti, S. Oncogene (1998) [Pubmed]
  3. Targeting of T cells to CEA-expressing tumor cells by chimeric immune receptors with a highly specific single-chain anti-CEA activity. Arakawa, F., Shibaguchi, H., Xu, Z., Kuroki, M. Anticancer Res. (2002) [Pubmed]
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