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Gene Review

Tomm40  -  translocase of outer mitochondrial...

Rattus norvegicus

Synonyms: Mitochondrial import receptor subunit TOM40 homolog, Mitochondrial outer membrane protein of 38 kDa, OM38, TOM40, Tom40, ...
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High impact information on Tomm40

  • Immunoprecipitation demonstrated that OM38 is associated with the major import receptors rTOM20 and rTOM22, and several other unidentified components with molecular masses of 5-10 kDa in digitonin-solubilized membrane: OM10, OM7.5, and OM5 [1].
  • No formation of 5alpha-reduced forms of Org 4060, Org OM38, or Org 34694 was found, while formation of minor amounts of 3alpha-OH-Org 4060 and 3alpha-OH-Org OM38 could be demonstrated in both uterus, vagina, and aorta [2].

Associations of Tomm40 with chemical compounds

  • Blue native polyacrylamide gel electrophoresis revealed that OM38 is a component of a approximately 400-kDa complex, firmly associating with rTOM22 and loosely associating with rTOM20 [1].


  1. Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane. Suzuki, H., Okazawa, Y., Komiya, T., Saeki, K., Mekada, E., Kitada, S., Ito, A., Mihara, K. J. Biol. Chem. (2000) [Pubmed]
  2. Metabolism of norethisterone and norethisterone derivatives in rat uterus, vagina, and aorta. Blom, M.J., Wassink, M.G., van Wijk, F., Ederveen, A.G., Kloosterboer, H.J., Verhoeven, C.H., Lambert, J.G., Goos, H.J. Drug Metab. Dispos. (2001) [Pubmed]
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