The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ptch1  -  patched 1

Danio rerio

Synonyms: SO:0000704, lep, ptc1, ptc2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ptc2

  • A gene encoding a receptor for the hedgehog protein, ptc-2, is expressed by retinal neuroepithelial cells [1].
  • We find that at the sequence level Zf-ptc2 is more closely related than Zf-ptc1 to the ptc genes initially characterised in other vertebrate species [2].

Biological context of ptc2

  • Although this suggested an involvement of Hh signaling in TCDD-mediated impairment of jaw growth, we did not observe downregulation of ptc1 and ptc2, receptors dependent on Hh signaling [3].


  1. Function for Hedgehog genes in zebrafish retinal development. Stenkamp, D.L., Frey, R.A., Prabhudesai, S.N., Raymond, P.A. Dev. Biol. (2000) [Pubmed]
  2. Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling. Lewis, K.E., Concordet, J.P., Ingham, P.W. Dev. Biol. (1999) [Pubmed]
  3. Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression. Teraoka, H., Dong, W., Okuhara, Y., Iwasa, H., Shindo, A., Hill, A.J., Kawakami, A., Hiraga, T. Aquat. Toxicol. (2006) [Pubmed]
WikiGenes - Universities