Gene Review:
ptc - patched
Drosophila melanogaster
Synonyms:
BcDNA:RH36596, CG2411, Conf, Dmel\CG2411, Hedgehog receptor, ...
- The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human. Parisi, M.J., Lin, H. Cell Res. (1998)
- Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Duman-Scheel, M., Weng, L., Xin, S., Du, W. Nature (2002)
- Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Hahn, H., Wojnowski, L., Zimmer, A.M., Hall, J., Miller, G., Zimmer, A. Nat. Med. (1998)
- The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Wetmore, C., Eberhart, D.E., Curran, T. Cancer Res. (2000)
- Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Denef, N., Neubüser, D., Perez, L., Cohen, S.M. Cell (2000)
- Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Burke, R., Nellen, D., Bellotto, M., Hafen, E., Senti, K.A., Dickson, B.J., Basler, K. Cell (1999)
- The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Hooper, J.E., Scott, M.P. Cell (1989)
- Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Ho, K.S., Suyama, K., Fish, M., Scott, M.P. Development (2005)
- patched overexpression causes loss of wingless expression in Drosophila embryos. Schuske, K., Hooper, J.E., Scott, M.P. Dev. Biol. (1994)
- Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Alexandre, C., Jacinto, A., Ingham, P.W. Genes Dev. (1996)
- Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing. Glise, B., Jones, D.L., Ingham, P.W. Dev. Biol. (2002)
- oroshigane, a new segment polarity gene of Drosophila melanogaster, functions in hedgehog signal transduction. Epps, J.L., Jones, J.B., Tanda, S. Genetics (1997)
- Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant-negative mechanism. Hime, G.R., Lada, H., Fietz, M.J., Gillies, S., Passmore, A., Wicking, C., Wainwright, B.J. Dev. Dyn. (2004)
- Molecular and cellular analysis of embryonic avian tongue development. Huang, R., Lang, E.R., Otto, W.R., Christ, B., Patel, K. Anat. Embryol. (2001)
- Chromophore-assisted laser inactivation of patched protein switches cell fate in the larval visual system of Drosophila. Schmucker, D., Su, A.L., Beermann, A., Jäckle, H., Jay, D.G. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Regulation of patched by sonic hedgehog in the developing neural tube. Marigo, V., Tabin, C.J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Lepage, T., Cohen, S.M., Diaz-Benjumea, F.J., Parkhurst, S.M. Nature (1995)
- Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Strutt, H., Thomas, C., Nakano, Y., Stark, D., Neave, B., Taylor, A.M., Ingham, P.W. Curr. Biol. (2001)
- In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Chen, Y., Struhl, G. Development (1998)
- Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein. Casali, A., Struhl, G. Nature (2004)
- Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed. Sanicola, M., Sekelsky, J., Elson, S., Gelbart, W.M. Genetics (1995)
- Hedgehog and its patched-smoothened receptor complex: a novel signalling mechanism at the cell surface. Alcedo, J., Noll, M. Biol. Chem. (1997)
- The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Tabata, T., Eaton, S., Kornberg, T.B. Genes Dev. (1992)
- The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. Capdevila, J., Estrada, M.P., Sánchez-Herrero, E., Guerrero, I. EMBO J. (1994)
- Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Lessing, D., Nusse, R. Development (1998)
- Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs. Alves, G., Limbourg-Bouchon, B., Tricoire, H., Brissard-Zahraoui, J., Lamour-Isnard, C., Busson, D. Mech. Dev. (1998)
- The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. Karpen, H.E., Bukowski, J.T., Hughes, T., Gratton, J.P., Sessa, W.C., Gailani, M.R. J. Biol. Chem. (2001)