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Gene Review

PTCH1  -  patched 1

Gallus gallus

Synonyms: PTC, PTCH
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High impact information on PTCH1

  • We show that Shh expression domains are lost from the talpid(3) head--in hindbrain, midbrain, zona limitans intrathalamica, and stomodeal ectoderm--and that direct targets of Hedgehog signaling, Ptc1, Ptc2, and Gli1, are also absent even in areas associated with primary Shh expression [1].

Anatomical context of PTCH1

  • Dorsally expressed Shh signals induce ectopic transcription of its receptor Ptc1 in the midbrain and the hindbrain [2].


  1. Craniofacial development in the talpid3 chicken mutant. Buxton, P., Davey, M.G., Paton, I.R., Morrice, D.R., Francis-West, P.H., Burt, D.W., Tickle, C. Differentiation (2004) [Pubmed]
  2. Sonic hedgehog-mediated ventralization disrupts formation of the midbrain-hindbrain junction in the chick embryo. Zhang, X.M., Lin, E., Yang, X.J. Dev. Neurosci. (2000) [Pubmed]
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