Toftgård,
Knauth,
Schlüter,
Czubayko,
Kirsch,
Florian,
Schreckenberger,
Hahn,
Bohnensack,
Rahnama,
Shimokawa,
Lauth,
Finta,
Kogerman,
Teglund,
Toftgård,
Zaphiropoulos,
Fischer,
Taysavang,
Jhiang,
Wechsler-Reya,
Scott,
Schön,
Reifenberger,
Von Schmiedeberg,
Megahed,
Lang,
Gattermann,
Meckenstock,
Goerz,
Ruzicka,
- Mutations in SUFU predispose to medulloblastoma. Taylor, M.D., Liu, L., Raffel, C., Hui, C.C., Mainprize, T.G., Zhang, X., Agatep, R., Chiappa, S., Gao, L., Lowrance, A., Hao, A., Goldstein, A.M., Stavrou, T., Scherer, S.W., Dura, W.T., Wainwright, B., Squire, J.A., Rutka, J.T., Hogg, D. Nat. Genet. (2002)
- Activating Smoothened mutations in sporadic basal-cell carcinoma. Xie, J., Murone, M., Luoh, S.M., Ryan, A., Gu, Q., Zhang, C., Bonifas, J.M., Lam, C.W., Hynes, M., Goddard, A., Rosenthal, A., Epstein, E.H., de Sauvage, F.J. Nature (1998)
- Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Aszterbaum, M., Epstein, J., Oro, A., Douglas, V., LeBoit, P.E., Scott, M.P., Epstein, E.H. Nat. Med. (1999)
- The developmental biology of brain tumors. Wechsler-Reya, R., Scott, M.P. Annu. Rev. Neurosci. (2001)
- Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. Tang, X., Kim, A.L., Feith, D.J., Pegg, A.E., Russo, J., Zhang, H., Aszterbaum, M., Kopelovich, L., Epstein, E.H., Bickers, D.R., Athar, M. J. Clin. Invest. (2004)
- Ptc1p regulates cortical ER inheritance via Slt2p. Du, Y., Walker, L., Novick, P., Ferro-Novick, S. EMBO J. (2006)
- Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene. Borrello, M.G., Alberti, L., Fischer, A., Degl'innocenti, D., Ferrario, C., Gariboldi, M., Marchesi, F., Allavena, P., Greco, A., Collini, P., Pilotti, S., Cassinelli, G., Bressan, P., Fugazzola, L., Mantovani, A., Pierotti, M.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- DHPLC analysis of patients with Nevoid Basal Cell Carcinoma Syndrome reveals novel PTCH missense mutations in the sterol-sensing domain. Marsh, A., Wicking, C., Wainwright, B., Chenevix-Trench, G. Hum. Mutat. (2005)
- Vertebral abnormalities associated with synthetic retinoid use. Gerber, L.H., Helfgott, R.K., Gross, E.G., Hicks, J.E., Ellenberg, S.S., Peck, G.L. J. Am. Acad. Dermatol. (1984)
- Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident. Wicking, C., Shanley, S., Smyth, I., Gillies, S., Negus, K., Graham, S., Suthers, G., Haites, N., Edwards, M., Wainwright, B., Chenevix-Trench, G. Am. J. Hum. Genet. (1997)
- Characterization of two patched receptors for the vertebrate hedgehog protein family. Carpenter, D., Stone, D.M., Brush, J., Ryan, A., Armanini, M., Frantz, G., Rosenthal, A., de Sauvage, F.J. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Detecting tissue-specific alternative splicing and disease-associated aberrant splicing of the PTCH gene with exon junction microarrays. Nagao, K., Togawa, N., Fujii, K., Uchikawa, H., Kohno, Y., Yamada, M., Miyashita, T. Hum. Mol. Genet. (2005)
- Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas. Dahmen, R.P., Koch, A., Denkhaus, D., Tonn, J.C., Sörensen, N., Berthold, F., Behrens, J., Birchmeier, W., Wiestler, O.D., Pietsch, T. Cancer Res. (2001)
- Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Reifenberger, J., Wolter, M., Weber, R.G., Megahed, M., Ruzicka, T., Lichter, P., Reifenberger, G. Cancer Res. (1998)
- PTCH gene mutations in invasive transitional cell carcinoma of the bladder. McGarvey, T.W., Maruta, Y., Tomaszewski, J.E., Linnenbach, A.J., Malkowicz, S.B. Oncogene (1998)
- Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. Oniscu, A., James, R.M., Morris, R.G., Bader, S., Malcomson, R.D., Harrison, D.J. J. Pathol. (2004)
- Analysis of genetic and phenotypic heterogeneity in juvenile polyposis. Woodford-Richens, K., Bevan, S., Churchman, M., Dowling, B., Jones, D., Norbury, C.G., Hodgson, S.V., Desai, D., Neale, K., Phillips, R.K., Young, J., Leggett, B., Dunlop, M., Rozen, P., Eng, C., Markie, D., Rodriguez-Bigas, M.A., Sheridan, E., Iwama, T., Eccles, D., Smith, G.T., Kim, J.C., Kim, K.M., Sampson, J.R., Evans, G., Tejpar, S., Bodmer, W.F., Tomlinson, I.P., Houlston, R.S. Gut (2000)
- Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome. Tanioka, M., Takahashi, K., Kawabata, T., Kosugi, S., Murakami, K., Miyachi, Y., Nishigori, C., Iizuka, T. Arch. Dermatol. Res. (2005)
- Allelic loss at Drosophila patched gene is highly prevalent in Basal and squamous cell carcinomas of the skin. Danaee, H., Karagas, M.R., Kelsey, K.T., Perry, A.E., Nelson, H.H. J. Invest. Dermatol. (2006)
- Multiple basal cell carcinomas associated with hairy cell leukaemia. Schön, M.P., Reifenberger, J., Von Schmiedeberg, S., Megahed, M., Lang, K., Gattermann, N., Meckenstock, G., Goerz, G., Ruzicka, T. Br. J. Dermatol. (1999)
- Identification of a novel polymorphism involving a CGG repeat in the PTCH gene and a genome-wide screening of CGG-containing genes. Nagao, K., Fujii, K., Yamada, M., Miyashita, T. J. Hum. Genet. (2004)
- Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly. Ming, J.E., Kaupas, M.E., Roessler, E., Brunner, H.G., Golabi, M., Tekin, M., Stratton, R.F., Sujansky, E., Bale, S.J., Muenke, M. Hum. Genet. (2002)
- Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking. Knauth, P., Schlüter, T., Czubayko, M., Kirsch, C., Florian, V., Schreckenberger, S., Hahn, H., Bohnensack, R. J. Mol. Biol. (2005)
- Inhibition of GLI1 gene activation by Patched1. Rahnama, F., Shimokawa, T., Lauth, M., Finta, C., Kogerman, P., Teglund, S., Toftgård, R., Zaphiropoulos, P.G. Biochem. J. (2006)
- Hedgehog signalling in cancer. Toftgård, R. Cell. Mol. Life Sci. (2000)
- UV mutation signature in tumor suppressor genes involved in skin carcinogenesis in xeroderma pigmentosum patients. D'Errico, M., Calcagnile, A., Canzona, F., Didona, B., Posteraro, P., Cavalieri, R., Corona, R., Vorechovsky, I., Nardo, T., Stefanini, M., Dogliotti, E. Oncogene (2000)
- GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. Shin, S.H., Kogerman, P., Lindström, E., Toftgárd, R., Biesecker, L.G. Proc. Natl. Acad. Sci. U.S.A. (1999)
- RET/Papillary Thyroid Carcinoma Oncogenic Signaling through the Rap1 Small GTPase. De Falco, V., Castellone, M.D., De Vita, G., Cirafici, A.M., Hershman, J.M., Guerrero, C., Fusco, A., Melillo, R.M., Santoro, M. Cancer Res. (2007)
- APC mutations in sporadic medulloblastomas. Huang, H., Mahler-Araujo, B.M., Sankila, A., Chimelli, L., Yonekawa, Y., Kleihues, P., Ohgaki, H. Am. J. Pathol. (2000)
- Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. Tostar, U., Malm, C.J., Meis-Kindblom, J.M., Kindblom, L.G., Toftgård, R., Undén, A.B. J. Pathol. (2006)
- Immunolocalization of PTCH protein in odontogenic cysts and tumors. Barreto, D.C., Bale, A.E., De Marco, L., Gomez, R.S. J. Dent. Res. (2002)
- Mutations of the p53 and PTCH gene in basal cell carcinomas: UV mutation signature and strand bias. Kim, M.Y., Park, H.J., Baek, S.C., Byun, D.G., Houh, D. J. Dermatol. Sci. (2002)
- Rhabdomyosarcoma, Wilms tumor, and deletion of the patched gene in Gorlin syndrome. Cajaiba, M.M., Bale, A.E., Alvarez-Franco, M., McNamara, J., Reyes-M??gica, M. Nature clinical practice. Oncology. (2006)
- Nuclear envelope irregularity is induced by RET/PTC during interphase. Fischer, A.H., Taysavang, P., Jhiang, S.M. Am. J. Pathol. (2003)