Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

gro1 - groucho 1

Danio rerio

This record was replaced with 100007463.

Nakada, C. et al., Runko, A.P. et al., Kawamura, A. et al.

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High impact information on gro1

Supporting this notion, foxl1 suppressed isolated 2.7-kb shh promoter activity in PC12 cells, and the minimal region of foxl1 required for its transcriptional repressor activity showed strong homology with the groucho binding motif, which is found in genes encoding various homeodomain proteins [1].
To interfere with endogenous nlz function, we generated a form of nlz that lacks the Groucho binding site and demonstrate that this construct has a dominant negative effect [2].

Anatomical context of gro1

Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites [3].

References

Transcriptional Repressor foxl1 Regulates Central Nervous System Development by Suppressing shh Expression in Zebra Fish. Nakada, C., Satoh, S., Tabata, Y., Arai, K., Watanabe, S. Mol. Cell. Biol. (2006) [Pubmed]
Nlz belongs to a family of zinc-finger-containing repressors and controls segmental gene expression in the zebrafish hindbrain. Runko, A.P., Sagerström, C.G. Dev. Biol. (2003) [Pubmed]
Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. Kawamura, A., Koshida, S., Hijikata, H., Ohbayashi, A., Kondoh, H., Takada, S. Dev. Cell (2005) [Pubmed]

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