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Gene Review

puf60b  -  poly-U binding splicing factor b

Danio rerio

Synonyms: Poly(U)-binding-splicing factor PUF60-B, SIAHBP1, SO:0000704, fe37c05, puf60, ...
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High impact information on zgc:86806

  • The relative nuclear concentrations of Gli activator (Gli(act)) and repressor (Gli(rep)) forms, together with their nucleocytoplasmic trafficking, appear to be critical determinants for target gene expression [1].
  • In this process, her5 acts as an active transcriptional repressor [2].
  • Here we characterized a zebrafish mutant--too few (tof)--that develops hindbrain 5HT and noradrenergic neurons, but does not develop hypothalamic DA and 5HT neurons. tof encodes a forebrain-specific zinc finger transcription repressor that is homologous to the mammalian Fezl (forebrain embryonic zinc finger-like protein) [3].
  • Both the eh1-related repressor motif and the second zinc finger domain were necessary for tof function [3].
  • Supporting this notion, foxl1 suppressed isolated 2.7-kb shh promoter activity in PC12 cells, and the minimal region of foxl1 required for its transcriptional repressor activity showed strong homology with the groucho binding motif, which is found in genes encoding various homeodomain proteins [4].

Biological context of zgc:86806

  • Expression of zfoxl1-EnR (repressing) rather than zfoxl1-VP16 (activating) resulted in a phenotype similar to that induced by foxl1-mRNA, suggesting that foxl1 may act as a transcriptional repressor of shh in zebra fish embryos [4].
  • Fusions of Her3 to the transactivation domain of VP16 and to the repression domain of Engrailed show that Her3 is indeed a transcriptional repressor [5].
  • Rev-erbalpha is a ubiquitously expressed orphan nuclear receptor which functions as a constitutive transcriptional repressor and is expressed in vertebrates according to a robust circadian rhythm [6].
  • The gastrula organizer forms in the dorsal region of the zebrafish embryo, where the bozozok/dharma homeobox gene downregulates expression of the vega1 transcriptional repressor [7].
  • Amino acid sequence comparisons of the HyD of HOXA11 suggested that a putative repressor subdomain, containing stretches of consecutive alanine residues, emerged within the tetrapods [8].

Anatomical context of zgc:86806


Associations of zgc:86806 with chemical compounds


Other interactions of zgc:86806

  • Dharma/Bozozok (Dha/Boz) is a homeodomain protein containing an Engrailed homology (Eh) 1 repressor motif [14].
  • Notably, Bozozok appears to function by repressing transcription of target genes such as swr (bmp2b) gene, and as such is the earliest acting repressor that the nascent dorsal axis is using to antagonize ventral influences [15].
  • We show that during early regeneration, proliferating blastemal cells express msxb, a homeodomain transcriptional repressor [16].
  • These results suggest that ved is a target for the repressor Dha/Boz [14].
  • Expression of a Dha/Boz fused to the transcriptional activator VP16 repressed dorsal axis formation and the expression of organizer genes but led to the dorsal expansion of expression of the homeobox gene vox/vega1, indicating that Dha/Boz functions as a transcriptional repressor for dorsal axis formation [14].


  1. iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Wolff, C., Roy, S., Lewis, K.E., Schauerte, H., Joerg-Rauch, G., Kirn, A., Weiler, C., Geisler, R., Haffter, P., Ingham, P.W. Genes Dev. (2004) [Pubmed]
  2. Coregulation of anterior and posterior mesendodermal development by a hairy-related transcriptional repressor. Bally-Cuif, L., Goutel, C., Wassef, M., Wurst, W., Rosa, F. Genes Dev. (2000) [Pubmed]
  3. Zinc finger protein too few controls the development of monoaminergic neurons. Levkowitz, G., Zeller, J., Sirotkin, H.I., French, D., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W.S., Rosenthal, A. Nat. Neurosci. (2003) [Pubmed]
  4. Transcriptional Repressor foxl1 Regulates Central Nervous System Development by Suppressing shh Expression in Zebra Fish. Nakada, C., Satoh, S., Tabata, Y., Arai, K., Watanabe, S. Mol. Cell. Biol. (2006) [Pubmed]
  5. her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling. Hans, S., Scheer, N., Riedl, I., v Weizsäcker, E., Blader, P., Campos-Ortega, J.A. Development (2004) [Pubmed]
  6. The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker. Triqueneaux, G., Thenot, S., Kakizawa, T., Antoch, M.P., Safi, R., Takahashi, J.S., Delaunay, F., Laudet, V. J. Mol. Endocrinol. (2004) [Pubmed]
  7. Functional interaction of vega2 and goosecoid homeobox genes in zebrafish. Kawahara, A., Wilm, T., Solnica-Krezel, L., Dawid, I.B. Genesis (2000) [Pubmed]
  8. Evolution of Hoxa-11 in lineages phylogenetically positioned along the fin-limb transition. Chiu, C.H., Nonaka, D., Xue, L., Amemiya, C.T., Wagner, G.P. Mol. Phylogenet. Evol. (2000) [Pubmed]
  9. Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm. Bakkers, J., Hild, M., Kramer, C., Furutani-Seiki, M., Hammerschmidt, M. Dev. Cell (2002) [Pubmed]
  10. Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells. Inoue, T., Terada, K., Furukawa, A., Koike, C., Tamaki, Y., Araie, M., Furukawa, T. BMC Dev. Biol. (2006) [Pubmed]
  11. Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. Kawamura, A., Koshida, S., Hijikata, H., Ohbayashi, A., Kondoh, H., Takada, S. Dev. Cell (2005) [Pubmed]
  12. Overexpression of thyroid hormone receptor alpha 1 during zebrafish embryogenesis disrupts hindbrain patterning and implicates retinoic acid receptors in the control of hox gene expression. Essner, J.J., Johnson, R.G., Hackett, P.B. Differentiation (1999) [Pubmed]
  13. The zebrafish thyroid hormone receptor alpha 1 is expressed during early embryogenesis and can function in transcriptional repression. Essner, J.J., Breuer, J.J., Essner, R.D., Fahrenkrug, S.C., Hackett, P.B. Differentiation (1997) [Pubmed]
  14. A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish. Shimizu, T., Yamanaka, Y., Nojima, H., Yabe, T., Hibi, M., Hirano, T. Mech. Dev. (2002) [Pubmed]
  15. The role of the homeodomain protein Bozozok in zebrafish axis formation. Solnica-Krezel, L., Driever, W. Int. J. Dev. Biol. (2001) [Pubmed]
  16. A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration. Nechiporuk, A., Keating, M.T. Development (2002) [Pubmed]
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