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Gene Review

psen1  -  presenilin 1

Danio rerio

Synonyms: PS-1, Presenilin-1, SO:0000704, Zf-PS1, pre1, ...
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Psychiatry related information on psen1


High impact information on psen1

  • The Cytosolic Loop of the {gamma}-Secretase Component Presenilin Enhancer 2 Protects Zebrafish Embryos from Apoptosis [2].
  • The gamma-secretase complex, composed of presenilin, presenilin enhancer 2 (Pen-2), nicastrin, and Aph-1, catalyzes the final cleavage of amyloid precursor protein to generate the toxic amyloid beta protein, the major component of plaques in the brains of Alzheimer disease patients [2].
  • The amyloidogenic function of zf-PS1 depends on the conserved aspartate residue 374 within the seventh putative transmembrane domain [3].


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