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Gene Review: 

psen1  -  presenilin 1

Danio rerio

Synonyms: PS-1, Presenilin-1, SO:0000704, Zf-PS1, pre1, ...
 
 
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Psychiatry related information on psen1

 

High impact information on psen1

  • The Cytosolic Loop of the {gamma}-Secretase Component Presenilin Enhancer 2 Protects Zebrafish Embryos from Apoptosis [2].
  • The gamma-secretase complex, composed of presenilin, presenilin enhancer 2 (Pen-2), nicastrin, and Aph-1, catalyzes the final cleavage of amyloid precursor protein to generate the toxic amyloid beta protein, the major component of plaques in the brains of Alzheimer disease patients [2].
  • The amyloidogenic function of zf-PS1 depends on the conserved aspartate residue 374 within the seventh putative transmembrane domain [3].

References

  1. Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2. Groth, C., Nornes, S., McCarty, R., Tamme, R., Lardelli, M. Dev. Genes Evol. (2002) [Pubmed]
  2. The Cytosolic Loop of the {gamma}-Secretase Component Presenilin Enhancer 2 Protects Zebrafish Embryos from Apoptosis. Zetterberg, H., Campbell, W.A., Yang, H.W., Xia, W. J. Biol. Chem. (2006) [Pubmed]
  3. Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Leimer, U., Lun, K., Romig, H., Walter, J., Grünberg, J., Brand, M., Haass, C. Biochemistry (1999) [Pubmed]
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