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Gene Review:

calY - camelysin

Bacillus cereus E33L

Grass, G. et al., Fricke, B. et al.

Fricke, Drössler, Willhardt, Schierhorn, Menge, Rücknagel,

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Disease relevance of calY

Camelysin is a novel surface metalloproteinase from Bacillus cereus [1].

High impact information on calY

The complete sequence of the camelysin-encoding gene, calY, was determined by reverse PCR on the basis of the N-terminal sequence and some internal tryptic cleavage peptides [1].
Although the predicted amino acid sequence of CalY does not exhibit a typical metalloprotease consensus sequence, high-pressure liquid chromatography-purified camelysin contains one zinc ion per protein molecule [1].
Camelysin is strongly bound to the cell surface and can be solubilized only by detergents or butanol [1].
Camelysin interacts with proteins of the blood coagulation cascade and could facilitate the penetration of fibrin clots and of the extracellular matrix during bacterial invasion [2].

References

Camelysin is a novel surface metalloproteinase from Bacillus cereus. Grass, G., Schierhorn, A., Sorkau, E., Müller, H., Rücknagel, P., Nies, D.H., Fricke, B. Infect. Immun. (2004) [Pubmed]
The cell envelope-bound metalloprotease (camelysin) from Bacillus cereus is a possible pathogenic factor. Fricke, B., Drössler, K., Willhardt, I., Schierhorn, A., Menge, S., Rücknagel, P. Biochim. Biophys. Acta (2001) [Pubmed]

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