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Gene Review:

tbx6 - T-box gene 6

Danio rerio

Synonyms: SO:0000704, T-box 6, like, T-box protein 6, T-box protein 6L, T-box transcription factor TBX6, ...

Hug, B. et al., Goering, L.M. et al., Lardelli, M.

Lardelli,

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High impact information on tbx6

Here we demonstrate that three T-box genes expressed in the zebrafish mesoderm, no tail, spadetail, and tbx6, operate as a network of interacting genes to regulate region-specific gene expression and developmental fate [1].
Three observations link the expression of tbx6 to ventral mesoderm specification [2].
Transcription of tbx6 commences about an hour after initiation of expression of the pan-mesendodermal gene no tail and the organizer gene goosecoid [2].
The evolutionary relationships of zebrafish genes tbx6, tbx16/spadetail and mga [3].

Biological context of tbx6

The human genome does not appear to possess orthologues of zebrafish tbx6 or tbx16/spadetail [3].

References

An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm. Goering, L.M., Hoshijima, K., Hug, B., Bisgrove, B., Kispert, A., Grunwald, D.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
tbx6, a Brachyury-related gene expressed by ventral mesendodermal precursors in the zebrafish embryo. Hug, B., Walter, V., Grunwald, D.J. Dev. Biol. (1997) [Pubmed]
The evolutionary relationships of zebrafish genes tbx6, tbx16/spadetail and mga. Lardelli, M. Dev. Genes Evol. (2003) [Pubmed]

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