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Gene Review:

jak1 - Janus kinase 1

Danio rerio

Synonyms: JAK-1, SO:0000704, Tyrosine-protein kinase JAK1

Conway, G. et al., Hermann, A.C. et al.

Conway, Margoliath, Wong-Madden, Roberts, Gilbert,

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High impact information on jak1

Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos [1].
This work establishes that, in addition to its role in signal transduction of cytokines in adult tissues, Jak1 kinase has a role in early vertebrate development [1].
Injection of RNA-encoding dominant-negative Jak1 kinases reduces a specific cell migration, epiboly, and results in the reduction of goosecoid expression and of anterior structures [1].
In a search for tyrosine kinases expressed in early zebrafish embryos, a model system for the study of vertebrate development, we discovered Jak1 kinase to be maternally encoded and the mRNA evenly distributed among the cells of blastula-stage embryos [1].

Analytical, diagnostic and therapeutic context of jak1

Differences in IFN and MX : expression in arsenic-exposed larvae point toward an interruption of the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway [2].

References

Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos. Conway, G., Margoliath, A., Wong-Madden, S., Roberts, R.J., Gilbert, W. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Effects of arsenic on zebrafish innate immune system. Hermann, A.C., Kim, C.H. Mar. Biotechnol. (2005) [Pubmed]

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