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Gene Review

otpb  -  orthopedia homeobox b

Danio rerio

Synonyms: Homeobox protein orthopedia B, SO:0000704, cb977, otp, otp1, ...
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High impact information on otpa

  • Additionally, these studies demonstrate that otp is required for isotocin cell development [1].
  • In this paper we show that zebrafish otp mRNA expression in the embryonic forebrain is dynamic and complex, and that it overlaps with isotocin expression in the dorsal preoptic area [1].
  • BACKGROUND: The homeodomain transcription factor Orthopedia (Otp) is essential in restricting the fate of multiple classes of secreting neurons in the neuroendocrine hypothalamus of vertebrates [2].


  1. Zebrafish orthopedia (otp) is required for isotocin cell development. Eaton, J.L., Glasgow, E. Dev. Genes Evol. (2007) [Pubmed]
  2. Differential regulation of the zebrafish orthopedia1 gene during fate determination of diencephalic neurons. Del Giacco, L., Sordino, P., Pistocchi, A., Andreakis, N., Tarallo, R., Di Benedetto, B., Cotelli, F. BMC Dev. Biol. (2006) [Pubmed]
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