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Gene Review

OTP  -  orthopedia homeobox

Homo sapiens

Synonyms: Homeobox protein orthopedia
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Disease relevance of OTP

  • The influence of 8-bromo-cAMP on N-glycosylation in JEG-3 choriocarcinoma cells was investigated using the octanoyl-tripeptide (OTP; N-octanoyl-asparagyl-125I-tyrosyl-threonine amide) as glycosyl acceptor [1].
  • The exposure of human stomach cancer KATO III cells to oolong tea polyphenol extact [OTPE] containing oolong tea polyphenol trimer [OTP trimer] as a main component, led to both growth inhibition and the induction of apoptosis [2].

Psychiatry related information on OTP


High impact information on OTP

  • OTP provided important information about the main pancreatic duct when endoscopic visualization was unsuccessful (n = 23), incomplete (n = 17) or not performed (n = 33); there was a failure rate of 4 per cent [4].
  • RESULTS AND CONCLUSIONS: For target coverage, the volume receiving more than 95% of the prescribed dose ranged from 77% (OTP) to 91% (Eclipse and Pinnacle), the volume receiving more than 107% ranged from 3.3% (Hyperion) to 23.2% (OTP) [5].
  • The biochemical basis for metabolic shunting is significantly elevated hepatic UDP-glucuronic acid content, an increased calculated UDP-glucuronic acid synthetic rate, and an increased liver microsomal UDP-glucuronyl transferase activity in OTP-treated animals [6].
  • Previously, we demonstrated that oltipraz [OTP: 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] prevented the hepatotoxicity of acetaminophen (AAP) in hamsters and that the observed protection was not related to increases in hepatic reduced glutathione (GSH) levels [6].
  • OTPP showed a 5-fold stronger inhibition against pancreatic lipase (IC50 = 0.28 microg/mL) by comparison with that of the tannase-treated OTPP (IC50 = 1.38 microg/mL) [7].

Biological context of OTP

  • Secondary down-regulation of the OTP gene or of downstream genes such as BRN2 or SIM1 may result in failure of terminal differentiation of magnocellular neurons of the supraoptic and paraventricular hypothalamic nuclei [8].
  • Importantly, since OTP Sepharose binds PTP1B with an intact active site only, the method ensures that the purified enzyme is fully active, a feature that might be particularly important in PTP research [9].

Associations of OTP with chemical compounds

  • During the 6 cycles, only 8 patients did not recover a normal T at least once during the off-treatment periods (OTP) [10].
  • Inhibitory effects of 4'-oxythiamine pyrophosphate (OTPP) and tetrahydrothiamine pyrophosphate (ThTPP) on the purified bison heart pyruvate dehydrogenase complex (PDC) semisaturated with endogenous thiamine pyrophosphate (TPP) and 2-oxoglutarate dehydrogenase complex (OGDC) saturated about 85% with endogenous TPP, were studied [11].

Other interactions of OTP

  • The mean T values at the end of each OTP did not change during these 6 cycles (Anova test, p=0.621) with a mean stable recovery delay of 32-43 days (Anova test, p=0.722) [10].

Analytical, diagnostic and therapeutic context of OTP

  • On-table pancreatography (OTP) was performed by one of five different techniques: retrograde, prograde or ambigrade ductography, cystography and ascending loopography after pancreaticojejunostomy [4].
  • In 35 patients either the additional information or discrepancies between ERCP and OTP findings resulted in a change of operative plan (19 extra procedures, 16 altered procedures) [4].
  • The oolong tea polymerized polyphenols (OTPP) were prepared for the assay from oolong tea extract, from which the preparation effectively subtracted the zero and/or less-active monomeric flavan-3-ols by preparative high-performance liquid chromatography [7].


  1. Regulation of N-glycosylation. Long term effect of cyclic AMP mediates enhanced synthesis of the dolichol pyrophosphate core oligosaccharide. Konrad, M., Merz, W.E. J. Biol. Chem. (1994) [Pubmed]
  2. Oolong tea polyphenol extract induces apoptosis in human stomach cancer cells. Hibasami, H., Jin, Z.X., Hasegawa, M., Urakawa, K., Nakagawa, M., Ishii, Y., Yoshioka, K. Anticancer Res. (2000) [Pubmed]
  3. Early intervention for schizophrenic disorders. Implementing optimal treatment strategies in routine clinical services. OTP Collaborative Group. Falloon, I.R., Coverdale, J.H., Laidlaw, T.M., Merry, S., Kydd, R.R., Morosini, P. The British journal of psychiatry. Supplement. (1998) [Pubmed]
  4. On-table pancreatography: importance in planning operative strategy. Desa, L.A., Williamson, R.C. The British journal of surgery. (1990) [Pubmed]
  5. IMRT for breast. a planning study. Fogliata, A., Nicolini, G., Alber, M., Asell, M., Dobler, B., El-Haddad, M., Hårdemark, B., Jelen, U., Kania, A., Larsson, M., Lohr, F., Munger, T., Negri, E., Rodrigues, C., Cozzi, L. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2005) [Pubmed]
  6. Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. II. Competitive shunt in metabolism via glucuronidation. Davies, M.H., Schnell, R.C. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  7. Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. Nakai, M., Fukui, Y., Asami, S., Toyoda-Ono, Y., Iwashita, T., Shibata, H., Mitsunaga, T., Hashimoto, F., Kiso, Y. J. Agric. Food Chem. (2005) [Pubmed]
  8. Neuropathologic research strategies in holoprosencephaly. Sarnat, H.B., Flores-Sarnat, L. J. Child Neurol. (2001) [Pubmed]
  9. Affinity purification of recombinant protein-tyrosine phosphatase 1B using a highly selective inhibitor. Pedersen, A.K., Branner, S., Mortensen, S.B., Andersen, H.S., Klausen, K.M., Møller, K.B., Møller, N.P., Iversen, L.F. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2004) [Pubmed]
  10. Intermittent androgen castration: a biological reality during intermittent treatment in metastatic prostate cancer? Mottet, N., Lucas, C., Sene, E., Avances, C., Maubach, L., Wolff, J.M. Urologia internationalis. (2005) [Pubmed]
  11. Different extent of inhibition of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase both containing endogenous thiamine pyrophosphate, by some anticoenzyme analogues. Strumilo, S., Czygier, M., Markiewicz, J. J. Enzym. Inhib. (1996) [Pubmed]
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