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Gene Review

Efemp1  -  EGF-containing fibulin-like extracellular...

Rattus norvegicus

Synonyms: FIBL-3, Fbln3, Fibulin-3, T16 protein
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High impact information on Efemp1

  • Triton X-100 extractability was lower in F versus M at T16 (P < 0.05) [1].
  • Microsomal testosterone (T) T2 alpha- and T2 beta-hydroxylations were lower in livers of mature male dwarf rats than the normals, whereas T16 beta-hydroxylation was rather higher in male dwarf rats [2].
  • A data base search revealed that T16 exhibited a strong sequence similarity to the human epidermal growth factor (EGF)-like protein, S(1-5) [3].
  • One of the positive clones, T16, contained a cDNA sequence of 1934 nucleotides with a single open reading frame of 493 amino acids [3].

Analytical, diagnostic and therapeutic context of Efemp1

  • The left renal pedicle of uninephrectomized female (F) and male (M) Wistar rats was clamped for 55 min followed by 2 h (T2) and 16 h (T16) of reperfusion [1].


  1. Sex differences in the alterations of Na(+), K(+)-ATPase following ischaemia-reperfusion injury in the rat kidney. Fekete, A., Vannay, A., Vér, A., Vásárhelyi, B., Müller, V., Ouyang, N., Reusz, G., Tulassay, T., Szabó, A.J. J. Physiol. (Lond.) (2004) [Pubmed]
  2. Age- and sex-related alterations of microsomal drug- and testosterone-oxidizing cytochrome P450 in Sprague-Dawley strain-derived dwarf rats. Shimada, M., Murayama, N., Yamazoe, Y., Hashimoto, H., Ishikawa, H., Kato, R. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  3. Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5). Ozaki, T., Kondo, K., Nakamura, Y., Ichimiya, S., Nakagawara, A., Sakiyama, S. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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